CAJ | 학술논문

研究外用给药制剂盐酸青藤外敷散多次给药后有效成分盐酸青藤碱在实验大鼠局部组织的药代动力学，探索其在局部给药系统中的药动学行为．对实验大鼠后足造模并贴敷给药后，测定大鼠给药足组织内盐酸青藤碱的吸收量，并用PKSolver药动学软件进行药动学参数的计算与曲线的拟合．药动学参数Lambda＿z、Vz／F＿obs、Tmax、Css、DF％值分别为0．14 d－1、5．64 mL／mg、2 d、0．24 mg／mL、75％．从药动学数据可知药物在局部组织中含量较高，局部患处在高质量浓度的药物作用下，可达到较好的治疗效果，且外用局部给药可减少全身用药的不良反应，耐受性良好．
연구외용급약제제염산청등외부산다차급약후유효성분염산청등감재실험대서국부조직적약대동역학，탐색기재국부급약계통중적약동학행위．대실험대서후족조모병첩부급약후，측정대서급약족조직내염산청등감적흡수량，병용PKSolver약동학연건진행약동학삼수적계산여곡선적의합．약동학삼수Lambda＿z、Vz／F＿obs、Tmax、Css、DF％치분별위0．14 d－1、5．64 mL／mg、2 d、0．24 mg／mL、75％．종약동학수거가지약물재국부조직중함량교고，국부환처재고질량농도적약물작용하，가체도교호적치료효과，차외용국부급약가감소전신용약적불량반응，내수성량호．
To study pharmacokinetics of sinomenine hydrochloride which is the active ingredi-ent of Qingfangzhongtongwaifusan in local tissue of rats, and to explore the behavior of the topical drug delivery system through the experiment.After inducing animal model of human arthritis, the rats were applied to SHPEA in the form of transdermal administration.Subse-quently, the absorption of sinomenine hydrochloride was examined in dosed pedis of rats. The pharmacokinetics parameters were calculated and the curve was fitted by the PKS phar-macokinetic software automatically.The pharmacokinetic parameters were as follows Lambda_z(0.14)d-1, Vz/F_obs(5.64) mL/mg, Tmax(2)d, Css(0.24) mg/mL, DF%(75)%, respectively.The pharmacokinetic data showed that drug concentration was higher in local tissue of rats and the topical efficacy was powerful.With the effect of higher concentration of drug in topical lesions, it not only achieved a good treatment results but also reduced system adverse reactions.Topical delivery system also produced well toleration.