CAJ | 학술논문

目的：评价间断小剂量尿激酶溶栓治疗肺栓塞的疗效及安全性。方法：选择42例诊断肺栓塞患者随机分为两组：尿激酶（UK）组给予静脉滴注尿激酶，10000 U／（kg·次），每天1次，按100000 U／h 滴注，治疗时间为7 d；重组组织型纤溶酶原激活剂（rt-PA）组给予静脉滴注rt-PA，50 mg／2h，只用1次。两组治疗后第8、14天超声心动图评价右心室的功能，CT肺动脉造影评价改善肺血管缺损面积。评价两组不良反应（包括死亡、出血、再发）。结果：治疗8、14 d 两组在改善右心室功能及肺血管缺损面积差异无显著性（P ＞0．05），UK组出血发生率少于rt-PA组。结论：间断小剂量尿激酶溶栓方案治疗肺栓塞与 rt-PA方案有相同的疗效。
목적：평개간단소제량뇨격매용전치료폐전새적료효급안전성。방법：선택42례진단폐전새환자수궤분위량조：뇨격매（UK）조급여정맥적주뇨격매，10000 U／（kg·차），매천1차，안100000 U／h 적주，치료시간위7 d；중조조직형섬용매원격활제（rt-PA）조급여정맥적주rt-PA，50 mg／2h，지용1차。량조치료후제8、14천초성심동도평개우심실적공능，CT폐동맥조영평개개선폐혈관결손면적。평개량조불량반응（포괄사망、출혈、재발）。결과：치료8、14 d 량조재개선우심실공능급폐혈관결손면적차이무현저성（P ＞0．05），UK조출혈발생솔소우rt-PA조。결론：간단소제량뇨격매용전방안치료폐전새여 rt-PA방안유상동적료효。
Objective To evaluate the efficacy and safety of intermittent use of low-dose urokinase in the treatment of pulmonary embolism. Methods Forty-two patients with acute pulmonary embolism were divided into UK group with UK 10 000 U/(kg·d),7 days and rt-PA group with rt-PA 50 mg/2 h randomly. The efficacy was determined by the improvement of right heart dysfunction and perfusion defect 8 d and 14 d after the treatment. The bleeding incidence, death rate and PE recurrence were also evaluated. Results Differences of right heart dysfunction and perfusion defect between UK group and rt-PA group indicated no statistical significance (P >0.05).The rate of bleeding in UK group was lower than that of rt-PA group. Conclution The intermittent use of low-dose urokinase in the treatment of pulmonary embolism exhibits similar efficacy as rt-PA.