实用医学杂志
實用醫學雜誌
실용의학잡지
THE JOURNAL OF PRACTICAL MEDICINE
2015年
7期
1114-1116
,共3页
杨小兵%郭东风%倪娓娓%蒋建平
楊小兵%郭東風%倪娓娓%蔣建平
양소병%곽동풍%예미미%장건평
晚期氧化蛋白产物%维持性腹膜透析%葡萄糖暴露程度
晚期氧化蛋白產物%維持性腹膜透析%葡萄糖暴露程度
만기양화단백산물%유지성복막투석%포도당폭로정도
Advanced oxidation protein products%Maintenance peritoneal dialysis%Glucose exposure dose
目的：了解非糖尿病腹膜透析患者血清晚期氧化蛋白产物（AOPP）在不同透析液葡萄糖暴露量下的水平，探明血AOPP水平是否与腹膜透析液葡萄糖暴露程度相关。方法：对192例非糖尿病腹膜透析患者进行横断面研究。按透析液葡萄糖暴露量将患者分为高糖暴露组和低糖暴露组。检测所有患者空腹血清AOPP和C反应蛋白水平，记录两组患者的心血管疾病患病率。结果：高糖暴露组的血清AOPP水平显著高于低糖暴露组[（78．7±15．6）mmol／L vs （71．7±14．8）mmol／L， P ＝0．003]。高糖暴露组患者血C反应蛋白[4．6（3．0～11．4）mg／L vs 3．0（2．2～5．3）mg／L， P ＜0．001]和心血管疾病患病率（53．6％ vs 35．8％， P ＝0．014）均显著高于低糖暴露组。经多因素校正后，血清AOPP水平与透析液葡萄糖暴露量（β＝0．157， P ＝0．031）和透析时长（β＝0．164， P ＝0．043）独立相关。结论：非糖尿病腹膜透析患者血清AOPP水平与透析液葡萄糖暴露程度相关，减少葡萄糖暴露度可能降低非糖尿病腹膜透析患者的心血管疾病发生风险。
目的：瞭解非糖尿病腹膜透析患者血清晚期氧化蛋白產物（AOPP）在不同透析液葡萄糖暴露量下的水平，探明血AOPP水平是否與腹膜透析液葡萄糖暴露程度相關。方法：對192例非糖尿病腹膜透析患者進行橫斷麵研究。按透析液葡萄糖暴露量將患者分為高糖暴露組和低糖暴露組。檢測所有患者空腹血清AOPP和C反應蛋白水平，記錄兩組患者的心血管疾病患病率。結果：高糖暴露組的血清AOPP水平顯著高于低糖暴露組[（78．7±15．6）mmol／L vs （71．7±14．8）mmol／L， P ＝0．003]。高糖暴露組患者血C反應蛋白[4．6（3．0～11．4）mg／L vs 3．0（2．2～5．3）mg／L， P ＜0．001]和心血管疾病患病率（53．6％ vs 35．8％， P ＝0．014）均顯著高于低糖暴露組。經多因素校正後，血清AOPP水平與透析液葡萄糖暴露量（β＝0．157， P ＝0．031）和透析時長（β＝0．164， P ＝0．043）獨立相關。結論：非糖尿病腹膜透析患者血清AOPP水平與透析液葡萄糖暴露程度相關，減少葡萄糖暴露度可能降低非糖尿病腹膜透析患者的心血管疾病髮生風險。
목적：료해비당뇨병복막투석환자혈청만기양화단백산물（AOPP）재불동투석액포도당폭로량하적수평，탐명혈AOPP수평시부여복막투석액포도당폭로정도상관。방법：대192례비당뇨병복막투석환자진행횡단면연구。안투석액포도당폭로량장환자분위고당폭로조화저당폭로조。검측소유환자공복혈청AOPP화C반응단백수평，기록량조환자적심혈관질병환병솔。결과：고당폭로조적혈청AOPP수평현저고우저당폭로조[（78．7±15．6）mmol／L vs （71．7±14．8）mmol／L， P ＝0．003]。고당폭로조환자혈C반응단백[4．6（3．0～11．4）mg／L vs 3．0（2．2～5．3）mg／L， P ＜0．001]화심혈관질병환병솔（53．6％ vs 35．8％， P ＝0．014）균현저고우저당폭로조。경다인소교정후，혈청AOPP수평여투석액포도당폭로량（β＝0．157， P ＝0．031）화투석시장（β＝0．164， P ＝0．043）독립상관。결론：비당뇨병복막투석환자혈청AOPP수평여투석액포도당폭로정도상관，감소포도당폭로도가능강저비당뇨병복막투석환자적심혈관질병발생풍험。
Objective To investigate the association between the level of advanced oxidation protein products (AOPP) in serum and the dialysate glucose exposure dose in patients undergoing non-diabetic maintenance peritoneal dialysis (PD). Methods In this cross-sectional study, the levels of serum AOPP were measured in 192 non-diabetic PD patients. Based on the exposure dose of dialysate glucose , PD patients were assigned into the high-dose exposure and low-dose exposure groups. Serum C-reactive protein levels were also measured and the rates of cardio-vascular disease (CVD) were recorded in both groups. Results The levels of serum AOPP were higher in the high-dose exposure group, as compared with the low-dose exposure group [(78.7 ± 15.6) mmol/L vs. (71.7 ± 14.8) mmol/L, P = 0.003]. The serum C-reactive protein levels [4.6 (3.0-11.4) mg/L vs. 3.0 (2.2-5.3) mg/L, P < 0.001] and the rates of CVD (53.6% vs. 35.8%, P = 0.014) were also higher in the high-dose exposure group. After multivariate adjustment ,the level of serum AOPP was independently associated with dialysate glucose exposure dose (β = 0.157, P = 0.031) and duration of PD (β = 0.164, P =0.043). Conclusion The serum AOPP levels are associated with the dialysate glucose exposure doses in non-diabetic PD patients. Minimizing the glucose load might reduce the risk of developing CVD.
