CAJ | 학술논문

目的：检测信号传导和转录激活因子3（STAT3）和缺氧诱导因子1α（HIF-1α）在食管鳞状细胞癌（ESCC）组织中的表达，分析其临床病理及预后。方法：采用免疫组化SP法检测50例患者食管癌及癌旁组织中STAT3和HIF-1α的表达。结果：STAT3和HIF-1α在食管癌中的阳性表达率分别为70％、58％，显著高于癌旁组织（P ＜0．05）。 STAT3阳性表达与淋巴结转移、浸润深度及TNM分期密切相关，且与30个月生存率呈正相关（P ＜0．05）；而HIF1-α表达与淋巴结转移及组织学分级密切相关（P＜0．05），与预后无关。STAT3和HIF-1α的表达呈正相关（r ＝0．362，P ＜0．05）。结论：STAT3和HIF-1α在食管癌中频繁表达，它们表达升高可能与食管癌预后差有关。
목적：검측신호전도화전록격활인자3（STAT3）화결양유도인자1α（HIF-1α）재식관린상세포암（ESCC）조직중적표체，분석기림상병리급예후。방법：채용면역조화SP법검측50례환자식관암급암방조직중STAT3화HIF-1α적표체。결과：STAT3화HIF-1α재식관암중적양성표체솔분별위70％、58％，현저고우암방조직（P ＜0．05）。 STAT3양성표체여림파결전이、침윤심도급TNM분기밀절상관，차여30개월생존솔정정상관（P ＜0．05）；이HIF1-α표체여림파결전이급조직학분급밀절상관（P＜0．05），여예후무관。STAT3화HIF-1α적표체정정상관（r ＝0．362，P ＜0．05）。결론：STAT3화HIF-1α재식관암중빈번표체，타문표체승고가능여식관암예후차유관。
Objective To investigate the expressions of STAT3 and HIF-1α in esophageal squamous cell carcinoma (ESCC) and its relationships with clinical pathological characteristics and prognosis. Methods The expressions of STAT3 and HIF-1α protein were examined via immunohistochemistry in 50 cases of ESCC and normal esophageal mucosa tissue. Results In the immunohistochemistry of 50 ESCC , the positive expression rates of STAT3 and HIF-1α were 70% and 58%, respectively , significantly higher than those at the adjacent normal mucosa (P < 0.05). The expression of STAT3 in ESCC patients was significantly related to the lymph node metastasis, depth of invasion and TNM stage. The 30-month survival rates were positively correlated with the positive expression of STAT3 (P < 0.05). The expression of HIF-1α in ESCC patients was significantly related to the degree of differentiation and lymph node metastasis. The patients with HIF-1α negative had a higher cumulative survival rate than those with HIF-1α positive (P < 0.05), but the difference was not significant. STAT3 and HIF-1α were positively correlation with statistical significance (r = 0.362,P < 0.05). Conclusion STAT3 and HIF-1α are frequently expressed in ESCC. High expressions of STAT3 and HIF-1αmay contribute to the poor prognosis of human esophageal squamous cell carcinoma.