中国药理学通报
中國藥理學通報
중국약이학통보
CHINESE PHARMACOLOGICAL BULLETIN
2015年
5期
601-604,605
,共5页
呼晓雷%周继朋%陈小平
呼曉雷%週繼朋%陳小平
호효뢰%주계붕%진소평
ADMA%SDMA%AGXT2%二甲基精氨酸二甲胺水解酶%单核苷酸多态性%心脑血管疾病
ADMA%SDMA%AGXT2%二甲基精氨痠二甲胺水解酶%單覈苷痠多態性%心腦血管疾病
ADMA%SDMA%AGXT2%이갑기정안산이갑알수해매%단핵감산다태성%심뇌혈관질병
ADMA%SDMA%AGXT2%dimethylarginine dimeth-ylaminohydrolase%SNP%cardiovascular and cerebrovascular dis-eases
心脑血管疾病严重威胁人类健康，有效预防和治疗心脑血管疾病是当代医学研究的重点。非对称性二甲基精氨酸（asymmetric dimethylarginine，ADMA）和对称性二甲基精氨酸（symmetric dimethylarginine，SDMA）是心脑血管疾病或心脑血管事件独立的预测因子。丙氨酸－乙醛酸转氨酶2（al-anine-glyoxylate aminotransferase 2，AGXT2）是内源性 ADMA的水解酶之一，其表达缺失或活性降低可影响体内 ADMA的水平，而AGXT2的多个单核苷酸多态性与体内SDMA的水平明显相关。深入研究AGXT2在心脑血管疾病发生发展中的作用对以AGXT2为靶点开发新型心脑血管保护药物具有重要意义。该文就AGXT2参与 ADMA 的代谢及其与心脑血管疾病的最新研究进展进行综述。
心腦血管疾病嚴重威脅人類健康，有效預防和治療心腦血管疾病是噹代醫學研究的重點。非對稱性二甲基精氨痠（asymmetric dimethylarginine，ADMA）和對稱性二甲基精氨痠（symmetric dimethylarginine，SDMA）是心腦血管疾病或心腦血管事件獨立的預測因子。丙氨痠－乙醛痠轉氨酶2（al-anine-glyoxylate aminotransferase 2，AGXT2）是內源性 ADMA的水解酶之一，其錶達缺失或活性降低可影響體內 ADMA的水平，而AGXT2的多箇單覈苷痠多態性與體內SDMA的水平明顯相關。深入研究AGXT2在心腦血管疾病髮生髮展中的作用對以AGXT2為靶點開髮新型心腦血管保護藥物具有重要意義。該文就AGXT2參與 ADMA 的代謝及其與心腦血管疾病的最新研究進展進行綜述。
심뇌혈관질병엄중위협인류건강，유효예방화치료심뇌혈관질병시당대의학연구적중점。비대칭성이갑기정안산（asymmetric dimethylarginine，ADMA）화대칭성이갑기정안산（symmetric dimethylarginine，SDMA）시심뇌혈관질병혹심뇌혈관사건독립적예측인자。병안산－을철산전안매2（al-anine-glyoxylate aminotransferase 2，AGXT2）시내원성 ADMA적수해매지일，기표체결실혹활성강저가영향체내 ADMA적수평，이AGXT2적다개단핵감산다태성여체내SDMA적수평명현상관。심입연구AGXT2재심뇌혈관질병발생발전중적작용대이AGXT2위파점개발신형심뇌혈관보호약물구유중요의의。해문취AGXT2삼여 ADMA 적대사급기여심뇌혈관질병적최신연구진전진행종술。
Cardiovascular and cerebrovascular diseases have be-come a great health threat.Increasing evidence has shown that both asymmetric dimethylarginine (ADMA)and symmetric dim-ethylarginine (SDMA)play important and independent roles in the development of cardiovascular and cerebrovascular diseases as well as in the prediction of cardiovascular and cerebrovascular events.Alanine-glyoxylate aminotransferase 2 (AGXT2 )is re-cently observed to be involved in ADMA metabolism.Deficiency in the expression and activity of AGXT2 may thus play a role in the development of cardiovascular and cerebrovascular diseases by affecting ADMA levels in vivo.Several single-nucleotide poly-morphisms at AGXT2 locus are observed to be associated with plasma SDMA level.This review summarizes recent advances in AGXT2 and its role in ADMA metabolism and the clinical rele-vance.
