中国药理学通报
中國藥理學通報
중국약이학통보
CHINESE PHARMACOLOGICAL BULLETIN
2015年
5期
619-622
,共4页
凝血因子XI%血栓性疾病%抗栓药物%出血%单克隆抗体%反义寡核苷酸%多肽
凝血因子XI%血栓性疾病%抗栓藥物%齣血%單剋隆抗體%反義寡覈苷痠%多肽
응혈인자XI%혈전성질병%항전약물%출혈%단극륭항체%반의과핵감산%다태
coagulation factor XI%thromboembolic disease%an-tithrombotic drugs%bleeding%monoclonal antibody%antisense ol-igonucleotides%polypeptide
出血是目前临床抗栓药物防治最主要、最常见的并发症。近年来,有关凝血因子XI(FXI)与血栓性疾病发生相关的临床资料、FXI基因敲除动物或抑制FXI的抗栓实验均表明FXI是出血风险小的抗栓防治新靶点,针对FXI靶点的抗栓药物出血副作用小。
齣血是目前臨床抗栓藥物防治最主要、最常見的併髮癥。近年來,有關凝血因子XI(FXI)與血栓性疾病髮生相關的臨床資料、FXI基因敲除動物或抑製FXI的抗栓實驗均錶明FXI是齣血風險小的抗栓防治新靶點,針對FXI靶點的抗栓藥物齣血副作用小。
출혈시목전림상항전약물방치최주요、최상견적병발증。근년래,유관응혈인자XI(FXI)여혈전성질병발생상관적림상자료、FXI기인고제동물혹억제FXI적항전실험균표명FXI시출혈풍험소적항전방치신파점,침대FXI파점적항전약물출혈부작용소。
Thromboembolic diseases are major health problems worldwide,and remain the leading cause of mortality and disabil-ity at present.Bleeding is the most important complication of an-tithrombotic therapy for thromboembolism,therefore research and development of new antithrombotic drugs with lowered bleeding risk is a significant medical need.The data that elevated plasma levels of FXI are associated with thromboembolic diseases,se-vere FXI deficiency reduced incidence of DVT and ischemic stroke,and FXI deficiency or inhibition in animals shows protec-tive effects against thrombus formation supporting FXI as a novel antithrombotic target with lowered bleeding risk.This paper re-views the progress on FXI as a novel antithrombotic target and the inhibitors target FXI.