CAJ | 학술논문

组蛋白共价修饰通过乙酰化、甲基化、磷酸化等多种形式，影响基因的转录活性，参与疾病的发生与发展，是表观遗传学研究中的重要领域。越来越多的研究证实组蛋白共价修饰在肝脏疾病的发生与发展过程中扮演着重要角色。该文详细阐述与分析了组蛋白共价修饰在各类肝脏疾病中的具体作用及近年来的研究进展，以期能为各类肝病的治疗与药物的开发提供一定的理论支持。
조단백공개수식통과을선화、갑기화、린산화등다충형식，영향기인적전록활성，삼여질병적발생여발전，시표관유전학연구중적중요영역。월래월다적연구증실조단백공개수식재간장질병적발생여발전과정중분연착중요각색。해문상세천술여분석료조단백공개수식재각류간장질병중적구체작용급근년래적연구진전，이기능위각류간병적치료여약물적개발제공일정적이론지지。
Histone modification participates in the occurrence and development of the diseases though affecting gene transcrip-tion activity by acetylation,methylation,phosphorylation,and other forms.It is an important field in the study of epigenetics. Numerous studies have demonstrated that histone modification plays an important role in the occurrence and development of liv-er diseases.This paper reviews the recent progress in under-standing the role and mechanisms of histone modification in alco-holic liver disease,nonalcoholic fatty liver disease,viral hepati-tis,liver fibrosis and hepatocellular carcinoma,with an aim to provide a theoretical basis for the treatment of liver diseases and drug development.