CAJ | 학술논문

肺动脉高压是一种以肺血管阻力升高为特征，最终导致右心功能严重受限、衰竭甚至死亡的慢性进展性疾病。其组织病理学改变主要以肺血管重构为特点，而肺动脉平滑肌细胞在外周血管的异常增殖是肺血管重构的主要病理基础。该文主要对参与肺动脉平滑肌细胞增殖信号转导机制及信号转导抑制剂的研究进展作一综述。
폐동맥고압시일충이폐혈관조력승고위특정，최종도치우심공능엄중수한、쇠갈심지사망적만성진전성질병。기조직병이학개변주요이폐혈관중구위특점，이폐동맥평활기세포재외주혈관적이상증식시폐혈관중구적주요병리기출。해문주요대삼여폐동맥평활기세포증식신호전도궤제급신호전도억제제적연구진전작일종술。
Pulmonary artery hypertension (PAH ) is a chronic progressive disease characterized by a persistent elevation of pul-monary vascular pressure,and the disease would limit the right ventricular function severely,fail the organ and even lead to death in the end.The histopathological change of PAH is fea-tured by the restructuring of pulmonary vessels,and the abnor-mal reproduction of pulmonary artery smooth muscle cells (PASMCs)in peripheral vessels is the major pathological basis of pulmonary vascular restructuring.This paper mainly reviews the research advances on signal transduction mechanisms and their inhibitors in promoting the proliferation of pulmonary artery smooth muscle cells.