CAJ | 학술논문

目的：探讨大剂量静脉补充铁剂联合促红细胞生成素纠正腹膜透析患者肾性贫血的临床效果及护理措施。方法：将200例长期腹膜透析致肾性贫血的患者随机分为对照组与观察组各100例。对照组采用口服琥珀酸亚铁片（速力菲）治疗，观察组采用大剂量静脉补铁右旋糖酐铁（科莫非）治疗；疗程均为2个月，均同时使用基因重组人红细胞生成素（EPO）10000 U/周，皮下注射。观察比较两组临床疗效、输注安全性及不良反应情况，并实施积极护理。结果：治疗后两组患者血红蛋白、红细胞计数、红细胞压积、血清铁、血清铁蛋白、转铁蛋白饱和度各项指标均有显著升高（P <0.05），且观察组改善程度明显优于对照组（P
목적：탐토대제량정맥보충철제연합촉홍세포생성소규정복막투석환자신성빈혈적림상효과급호리조시。방법：장200례장기복막투석치신성빈혈적환자수궤분위대조조여관찰조각100례。대조조채용구복호박산아철편（속력비）치료，관찰조채용대제량정맥보철우선당항철（과막비）치료；료정균위2개월，균동시사용기인중조인홍세포생성소（EPO）10000 U/주，피하주사。관찰비교량조림상료효、수주안전성급불량반응정황，병실시적겁호리。결과：치료후량조환자혈홍단백、홍세포계수、홍세포압적、혈청철、혈청철단백、전철단백포화도각항지표균유현저승고（P <0.05），차관찰조개선정도명현우우대조조（P
Objective:To observe the clinical effect of intravenous supply of iron in large dose combined with the usage of erythropoietin in the correction of renal anemia of patients with peritoneal dialysis and nursing measures. Methods:200 patients with renal anemia caused by long - term peritoneal dialysis were randomly divided into the control group and the observation group(100 cases in each group). The patients in the control group were treated with oral Ferrous Succinate tablets and the patients in the observation group were intravenously given Iron Dextran in large dose;at the same time the patients in both groups were given subcutaneous injection of recombinant human erythropoietin(EPO)of 10 000 U per week and the course of treatment was 2 months. The clinical effect,safety and adverse reactions were observed and compared between the two groups. Results:After the treatment,indexes like hemoglobin,red blood cell count,hematocrit,ser-um iron,serum ferritin and transferrin saturation were significantly increased in the two groups(P < 0. 05),and the improvement of the pa-tients was significantly better in the observation group than the control group(P < 0. 05). Conclusion:The clinical effect of intravenous supply of iron in large dose combined with the usage of erythropoietin is better than oral treatment with Ferrous Succinate tablets in the cor-rection of renal anemia of patients with peritoneal dialysis,and at the same time close observation on patient's condition and corresponding nursing measures can reduce the adverse reactions of the treatment.