CAJ | 학술논문

目的：为了探讨肥胖儿童血清同型半胱氨酸（ Hcy ）与炎性递质之间是否存在相关关系以及其在儿童肥胖时的意义。方法选取2010年2—12月我院儿科门诊就诊符合单纯性肥胖诊断标准的儿童65例为肥胖组；同期选取正常体质健康儿童30例为对照组，两组之间年龄、性别经统计学比较无显著性差异。检测两组观察对象血清中Hcy、肿瘤坏死因子－α（ TNF－α）、白细胞介素6（ IL－6）、和高敏C反应蛋白（Hs－CRP）的水平，并进行统计学比较。结果（1）肥胖组儿童血清Hcy、TNF－α、IL－6和Hs－CRP浓度显著高于对照组，差异有显著意义（P＜0．01）。（2）直线相关分析表明，肥胖组儿童血清Hcy与TNF－α、IL－6、Hs－CRP的浓度水平呈明显正相关。结论单纯肥胖状态下儿童体内有慢性炎症反应存在。在肥胖儿童体内，血清同型半胱氨酸和TNF－α、IL－6和Hs－CRP呈高表达状态，预示着这些因子能够作为儿童肥胖的重要生物学标志物，从而有助于高危肥胖儿童的早期识别。
목적：위료탐토비반인동혈청동형반광안산（ Hcy ）여염성체질지간시부존재상관관계이급기재인동비반시적의의。방법선취2010년2—12월아원인과문진취진부합단순성비반진단표준적인동65례위비반조；동기선취정상체질건강인동30례위대조조，량조지간년령、성별경통계학비교무현저성차이。검측량조관찰대상혈청중Hcy、종류배사인자－α（ TNF－α）、백세포개소6（ IL－6）、화고민C반응단백（Hs－CRP）적수평，병진행통계학비교。결과（1）비반조인동혈청Hcy、TNF－α、IL－6화Hs－CRP농도현저고우대조조，차이유현저의의（P＜0．01）。（2）직선상관분석표명，비반조인동혈청Hcy여TNF－α、IL－6、Hs－CRP적농도수평정명현정상관。결론단순비반상태하인동체내유만성염증반응존재。재비반인동체내，혈청동형반광안산화TNF－α、IL－6화Hs－CRP정고표체상태，예시착저사인자능구작위인동비반적중요생물학표지물，종이유조우고위비반인동적조기식별。
Objective To study the relationship between serum homocysteine ( Hcy) and inflammatory factors in obese children and their clinical significances .Methods From February 2010 to December 2010, 65 cases of obese children and 30 non-obese healthy controls were enrolled into this study .There was no significant difference of the age and sex between the two groups .The concentration of serum Hcy ,TNF-α,IL-6 and Hs-CRP were determined.SPSS 16.0 was used for statistical analysis .Results The levels of serum Hcy, TNF-α, IL-6 and Hs-CRP in obese children were obviously higher than those in healthy controls (P<0.05).Linear correlation analysis showed serum Hcy was positively correlated with TNF -α, IL-6 and Hs -CRP in obese children.Conclusions There exist chronic inflammation reactions in obese children .The elevation of serum Hcy, TNF-α, Hs-CRP and IL-6 in obese children suggest that these indicators may be important biological markers contributing to early identification of children at high risk of obesity .