广州化工
廣州化工
엄주화공
GUANGZHOU CHEMICAL INDUSTRY AND TECHNOLOGY
2015年
8期
92-93,166
,共3页
R-(+)-2-(4-羟基苯氧基)丙酸%合成%工艺改进
R-(+)-2-(4-羥基苯氧基)丙痠%閤成%工藝改進
R-(+)-2-(4-간기분양기)병산%합성%공예개진
R-(+)-2-(4-hydroxyphenoxy) propionate%synthesis%technical improvement
以L－丙氨酸为原料，经氯化、醚化和水解三步反应，醚化反应中发生构型翻转，最终得到R－（＋）－2－（4－羟基苯氧基）丙酸。实验主要考察了反应温度、反应时间和原料配比等因素的影响，获得了最佳的反应条件，总收率达71.1％。并对未反应的对苯二酚和反应中生成的二取代物的处理进行了探讨，同时通过液相色谱对产品的纯度进行了检测。该工艺实现了反应条件温和、产率较高、污染小，适合工业化生产。
以L－丙氨痠為原料，經氯化、醚化和水解三步反應，醚化反應中髮生構型翻轉，最終得到R－（＋）－2－（4－羥基苯氧基）丙痠。實驗主要攷察瞭反應溫度、反應時間和原料配比等因素的影響，穫得瞭最佳的反應條件，總收率達71.1％。併對未反應的對苯二酚和反應中生成的二取代物的處理進行瞭探討，同時通過液相色譜對產品的純度進行瞭檢測。該工藝實現瞭反應條件溫和、產率較高、汙染小，適閤工業化生產。
이L－병안산위원료，경록화、미화화수해삼보반응，미화반응중발생구형번전，최종득도R－（＋）－2－（4－간기분양기）병산。실험주요고찰료반응온도、반응시간화원료배비등인소적영향，획득료최가적반응조건，총수솔체71.1％。병대미반응적대분이분화반응중생성적이취대물적처리진행료탐토，동시통과액상색보대산품적순도진행료검측。해공예실현료반응조건온화、산솔교고、오염소，괄합공업화생산。
Using optical L-Alanine as the starting material, R-(+)-2-(4-hydroxyphenoxy)-propionic acid was synthesized via chlorination, etherification and hydrolysis reaction, and the configuration was reversed in etherification reaction.The conditional test of reaction temperature and time, molar ratio to reactants were processed and a best technical condition was explored.The yield was up to 71.1%and the product structure was characterized by 1 H NMR and MS spectrum.The product purity was characterized by HPLC.This synthesis process features ready availability of raw materials, mild operating regime, high product yield, and insignificant environmental pollution, which was suitable for industrialized production.
