CAJ | 학술논문

目的：了解慢性腹膜透析病人的中心动脉脉压水平，分析其与心血管疾病（CVD）的关系。方法单中心横断面研究，共纳入234例维持性腹膜透析病人（均接受腹膜透析3月以上）。采用SphygmoCor无创主动脉脉波分析仪检测病人的中心动脉收缩压和舒张压，脉压=收缩压-舒张压。CVD定义为临床确诊的缺血性心脏病，心力衰竭，脑卒中和外周血管性疾病。结果有CVD的腹膜透析病人中心动脉脉压水平显著高于无CVD者（51.7±22.5 mmHg vs 43.7±17.8 mmHg，P=0.004），而肱动脉脉压在两组病人间无显著差异（66.7±25.3 mmHg vs 61.9±19.7 mmHg，P=0.106）。多因素Logistic回归分析后，中心动脉脉压仍独立与CVD相关（校正后OR 1.33，95%置信区间1.01-1.73，P=0.04）。结论高中心动脉脉压水平与慢性腹膜透析病人CVD相关。
목적：료해만성복막투석병인적중심동맥맥압수평，분석기여심혈관질병（CVD）적관계。방법단중심횡단면연구，공납입234례유지성복막투석병인（균접수복막투석3월이상）。채용SphygmoCor무창주동맥맥파분석의검측병인적중심동맥수축압화서장압，맥압=수축압-서장압。CVD정의위림상학진적결혈성심장병，심력쇠갈，뇌졸중화외주혈관성질병。결과유CVD적복막투석병인중심동맥맥압수평현저고우무CVD자（51.7±22.5 mmHg vs 43.7±17.8 mmHg，P=0.004），이굉동맥맥압재량조병인간무현저차이（66.7±25.3 mmHg vs 61.9±19.7 mmHg，P=0.106）。다인소Logistic회귀분석후，중심동맥맥압잉독립여CVD상관（교정후OR 1.33，95%치신구간1.01-1.73，P=0.04）。결론고중심동맥맥압수평여만성복막투석병인CVD상관。
Objective To evaluate the association between central pulse pressure level and cardiovascular diseases (CVD) in patients receiving maintenance peritoneal dialysis. Methods This cross-sectional study was conducted in 234 patients on maintenance peritoneal dialysis. Central pulse pressure levels were measured using a SphygmoCor analyzer, and cardiovascular diseases were defined as diagnosed ischemic heart disease, heart failure, stroke or peripheral vascular disease. Results The central pulse pressure levels of patients with CVD were significantly higher than those without CVD (51.7±22.5 vs 43.7 ± 17.8 mmHg, P=0.004), while the brachial pulse pressure levels were comparable between the two patient groups. After adjusting for brachial pulse pressure and other relevant risk factors, central pulse pressure level was found to independently associate with CVD (adjusted OR=1.33, 95%CI 1.01-1.73, P=0.04 ). Conclusion High central pulse pressure level may serve as a risk factor for CVD in patients on maintenance peritoneal dialysis.