CAJ | 학술논문

目的：评价激素替代疗法对围绝期综合征（PMS）患者中的治疗效果及安全性。方法选择焦作市第二人民医院门诊就诊的112例PMS患者，按照随机数字表法分为A、B两组，每组56例，A组患者予以谷维素片治疗，30 mg/次，3次/d。B组患者应用激素替代疗法进行治疗，临床疗效采用Kupperman评分进行评价。对两组患者的Kupperman评分、治疗前后的促卵泡激素、雌二醇、黄体生存素水平及子宫内膜厚度进行记录，并对两组患者治疗后不良反应进行观察。结果两组患者治疗后的Kupperman评分、促卵泡激素、黄体生存素水平显著低于治疗前（P均＜0.05），而雌二醇水平及子宫内膜厚度显著高于治疗前（P均＜0.05），而治疗后B组患者的Kupperman评分、促卵泡激素、黄体生存素水平显著低于A组（P均＜0.05），雌二醇水平及子宫内膜厚度显著高于A组（P均＜0.05）。且全部患者治疗后均<br>　　未见明显药物不良反应。结论激素替代疗法应用于PMS患者的治疗效果及安全性较满意，能够有效缓解患者的临床症状和改善其生活质量。
목적：평개격소체대요법대위절기종합정（PMS）환자중적치료효과급안전성。방법선택초작시제이인민의원문진취진적112례PMS환자，안조수궤수자표법분위A、B량조，매조56례，A조환자여이곡유소편치료，30 mg/차，3차/d。B조환자응용격소체대요법진행치료，림상료효채용Kupperman평분진행평개。대량조환자적Kupperman평분、치료전후적촉란포격소、자이순、황체생존소수평급자궁내막후도진행기록，병대량조환자치료후불량반응진행관찰。결과량조환자치료후적Kupperman평분、촉란포격소、황체생존소수평현저저우치료전（P균＜0.05），이자이순수평급자궁내막후도현저고우치료전（P균＜0.05），이치료후B조환자적Kupperman평분、촉란포격소、황체생존소수평현저저우A조（P균＜0.05），자이순수평급자궁내막후도현저고우A조（P균＜0.05）。차전부환자치료후균<br>　　미견명현약물불량반응。결론격소체대요법응용우PMS환자적치료효과급안전성교만의，능구유효완해환자적림상증상화개선기생활질량。
ObjectiveTo study the effect and safety of hormone replacement therapy in patients with perimenopausal syndrome (PMS).Methods112 patients with PMS from Jiaozuo Second People's Hospital were divided into group A and B randomly with 56 cases in each group, patients in group A were given oryzanol tablets treatment (30 mg a time, 3 times a day),patients in group were given hormone replacement therapy, clinical efifcacy were evaluated by Kupperman scores. Kupperman scores, follicle stimulating hormone, estradiol, corpus luteum surviving, endometrial thickness of the two groups before and after treatment were recorded, adverse reactions of the two groups were observed.Results Kupperman scores, follicle stimulating hormone and corpus luteum surviving in two groups after treatment were lower than before treatment significantly (allP<0.05), estradiol and endometrial thickness of the two groups before treatment were higher than after treatment signiifcantly (allP<0.05). Kupperman scores, follicle stimulating hormone and corpus luteum surviving in group B were lower than group A significantly (allP<0.05), estradiol and endometrial thickness in groups B were higher than group A signiifcantly (allP<0.05). All of the patients after treatment showed no obvious adverse drug reaction. ConclusionThe efficacy and safety of hormone replacement therapy in patients with PMS is favorable, the therapy can effectively relieve the clinical symptoms, and improve the quality of life in patients with PMS.