CAJ | 학술논문

细胞因子信号转导抑制因子（suppressor of cytokine signaling，SOCS）是一类可由多种细胞因子诱导产生，又能通过多种途径对细胞因子的信号转导进行负向调节的蛋白质分子。众多研究发现SOCS蛋白家族是一个非常重要的可以负向调节 JAK／STAT信号通路的分子家族。本文将着重阐述介绍SOCS家族在炎症和自身免疫性疾病中的作用。
세포인자신호전도억제인자（suppressor of cytokine signaling，SOCS）시일류가유다충세포인자유도산생，우능통과다충도경대세포인자적신호전도진행부향조절적단백질분자。음다연구발현SOCS단백가족시일개비상중요적가이부향조절 JAK／STAT신호통로적분자가족。본문장착중천술개소SOCS가족재염증화자신면역성질병중적작용。
The suppressor of cytokine signalling is a protein family which can be induced by various cytokines. But, it can negatively regulate the signal transduction of the cytokines through a variety of ways. Many studies were found that the SOCS family played an important role in negatively regulating the JAK/STAT signalling pathway. In this review, we will introduce the relationship between the SOCS and inflammation, autoimmune diseases.