CAJ | 학술논문

目的：探讨红花对糖尿病大鼠冠状动脉粥样硬化的治疗作用及作用机制。方法建立糖尿病性心脏病大鼠模型，将大鼠分三组：对照组、糖尿病组和红花注射液组。测定各组大鼠血浆血糖和血脂，并采用HE染色、Masson染色法对动脉粥样硬化冠脉的病变进行形态学观察。结果与对照组相比，糖尿病组大鼠HDL明显降低，LDL、TG、TC则明显升高，而红花注射组能够逆转上述改变，并有明显的统计学意义（ P ＜0.05）；HE染色结果显示，糖尿病组大鼠冠状动脉管壁变厚、管腔变窄，而红花注射组冠状动脉管壁明显变薄；Masson染色结果显示，糖尿病模型组大鼠冠状动脉管壁有大量胶原纤维分布，而红花注射组大鼠的冠状动脉管壁胶原数量明显减少。结论红花注射液具有改善糖尿病大鼠冠状动脉粥样硬化的作用。
목적：탐토홍화대당뇨병대서관상동맥죽양경화적치료작용급작용궤제。방법건립당뇨병성심장병대서모형，장대서분삼조：대조조、당뇨병조화홍화주사액조。측정각조대서혈장혈당화혈지，병채용HE염색、Masson염색법대동맥죽양경화관맥적병변진행형태학관찰。결과여대조조상비，당뇨병조대서HDL명현강저，LDL、TG、TC칙명현승고，이홍화주사조능구역전상술개변，병유명현적통계학의의（ P ＜0.05）；HE염색결과현시，당뇨병조대서관상동맥관벽변후、관강변착，이홍화주사조관상동맥관벽명현변박；Masson염색결과현시，당뇨병모형조대서관상동맥관벽유대량효원섬유분포，이홍화주사조대서적관상동맥관벽효원수량명현감소。결론홍화주사액구유개선당뇨병대서관상동맥죽양경화적작용。
Objective To explore the effects of safflower injection on experimental coronary atherosclerosis in diabetic cardiopa -thy.Methods Diabetic heart disease rat models were eslablished and rats were divided into three groups :control group ,diabetic group and safflower injection group.in arder to blood glucose and blood lipid in plasma of rats in each group , and observe morphological le-sions of atherosclerotic coronary artery by HE staining Masson staining.Results Compared with the control group , LDL significantly decreased in diabetic group rats , and HDL, TG, TC increased significantly , while safflower injection group ould reverse these changes with statistical significance ( P <0.05);HE staining results showed, coronary vascular tube wall thicken , lumen changed narrow in diabetic group rats , and coronary vascular wall of safflower injection group was thinner;Masson staining results showed , the coronary vessel wall of diabetic rats in the model group has a large distribution of collagen fiber , and the safflower injection group significantly reduced the umount of collagen the on the tube wall.Conclusion Safflower injection can improve the coronary atherosclerosis in dia-betic rats.