CAJ | 학술논문

目的：探讨多发性骨髓瘤（MM）患者血清中可溶性细胞间黏附分子1（sICAM-1）、促红细胞生成素（ EPO）和血管内皮生长因子（ VEGF）的表达水平及其临床应用价值。方法选择2011年7月至2013年4月在惠州市第一人民医院治疗的MM患者64例（ MM组）及24例健康体检者（健康对照组）为研究对象，分析MM组及健康对照组、不同临床分期及不同肿瘤量患者血清sICAM-1、EPO及VEGF的表达水平。结果健康对照组血清 sICAM-1、EPO 及 VEGF 表达水平分别为（287±81）μg／L、（14±6） U／L、（113±78） mg／L，MM组患者血清sICAM-1、EPO及VEGF表达水平分别为（375±102）μg／L、（36±14） U／L、（614±205） mg／L。 MM组患者血清sICAM-1、EPO及 VEGF表达水平均显著高于对照组（P＜0.05）；随着临床分期的增加，患者血清中 sICAM-1、EPO及 VEGF呈增加趋势，差异均有统计学意义（P＜0.05）；随着患者肿瘤量的增加，血清中 sICAM-1、EPO及 VEGF表达水平也显著升高（ P＜0.05）。结论 ICAM-1、EPO 及 VEGF在 MM 患者血清中呈现出高表达，且随着病程的加剧显著升高。因此，血清ICAM-1、EPO及VEGF表达水平的升高对于MM患者临床分期的判断及辅助监测患者病情进展情况有重要的参考价值。
목적：탐토다발성골수류（MM）환자혈청중가용성세포간점부분자1（sICAM-1）、촉홍세포생성소（ EPO）화혈관내피생장인자（ VEGF）적표체수평급기림상응용개치。방법선택2011년7월지2013년4월재혜주시제일인민의원치료적MM환자64례（ MM조）급24례건강체검자（건강대조조）위연구대상，분석MM조급건강대조조、불동림상분기급불동종류량환자혈청sICAM-1、EPO급VEGF적표체수평。결과건강대조조혈청 sICAM-1、EPO 급 VEGF 표체수평분별위（287±81）μg／L、（14±6） U／L、（113±78） mg／L，MM조환자혈청sICAM-1、EPO급VEGF표체수평분별위（375±102）μg／L、（36±14） U／L、（614±205） mg／L。 MM조환자혈청sICAM-1、EPO급 VEGF표체수평균현저고우대조조（P＜0.05）；수착림상분기적증가，환자혈청중 sICAM-1、EPO급 VEGF정증가추세，차이균유통계학의의（P＜0.05）；수착환자종류량적증가，혈청중 sICAM-1、EPO급 VEGF표체수평야현저승고（ P＜0.05）。결론 ICAM-1、EPO 급 VEGF재 MM 환자혈청중정현출고표체，차수착병정적가극현저승고。인차，혈청ICAM-1、EPO급VEGF표체수평적승고대우MM환자림상분기적판단급보조감측환자병정진전정황유중요적삼고개치。
Objective To investigate the expression levels of soluble inter-cellular adhesion molecule-1 (sICAM-1),erythropoietin(EPO) and vascular endoehelial growth factor(VEGF) in serum of patients with multiple myeloma(MM) and their clinical significance.Methods A total of 64 MM patients admitted in Huizhou First People's Hospital from Jul.2011 to Apr.2013 were selected as MM group and another 24 cases of healthy volunteers underwent physical examination during the same period in the hospital were selected as the control group.The serum expression levels of sICAM-1,EPO and VEGF in patients of different clini-cal stages and tumor volumes from both groups were analyzed.Results The serum expression levels of sICAM-1, EPO and VEGF in the control group were (287 ±81) μg/L,(14 ±6) U/L,(113 ±78) mg/L, and those in MM group were (375 ±102) μg/L,(36 ±14) U/L,(614 ±205) mg/L.Such expression lev-els of MM group were significantly higher than the control group (P<0.05);as the clinical stage rose,the serum expression levels of sICAM-1, EPO and VEGF showed an increasing trend,the differences were statis-tically significant(P<0.05);and along with the increase in tumor volumes of the patients,the serum expres-sion levels of sICAM-1, EPO and VEGF also significantly elevated(P<0.05).Conclusion ICAM-1,EPO and VEGF are highly expressed in the serum of patients with MM,and their expression levels significantly elevate along with the increasing of clinical stage and tumor volume ,which can provide important guidance for the determination of clinical stage of patients with multiple myeloma and auxiliary monitoring on the patients ’ situation.