牡丹江医学院学报
牡丹江醫學院學報
모단강의학원학보
JOURNAL OF MUDANJIANG MEDICAL COLLEGE
2015年
2期
1-4
,共4页
结直肠癌%MAPK蛋白%磷酸化%临床病理%生存率%相关性
結直腸癌%MAPK蛋白%燐痠化%臨床病理%生存率%相關性
결직장암%MAPK단백%린산화%림상병리%생존솔%상관성
colorectal cancer%MAPK protein%phosphorylation%clinical pathological%survival rates%The correlation
目的：研究结直肠腺癌患者MAPK蛋白磷酸化表达与临床病理及生存率的相关性。方法收集经病理科诊断、手术切除的原发结直肠腺癌患者的癌组织标本166例及其癌旁正常组织标本61例。采用免疫组织化学SABC染色方法检测P－ERK1／2蛋白磷酸化表达情况，并对病例进行临床病理资料数据统计和随访患者6～60月生存情况。结果（1）结直肠癌患者中61.45％癌组织P－ERK1／2蛋白表达高磷酸化；98.36％癌旁正常肠组织无磷酸化。（2）癌组织P－ERK1／2蛋白高磷酸化女性较男性患者表达率高，癌组织原发部位于结肠的P－ERK1／2蛋白高磷酸化较直肠癌的患者表达率高，两者差异有统计学意义（ P ＜0.05）；癌组织P－ERK1／2蛋白磷酸化高表达与患者年龄、临床分期、浸润深度、淋巴转移、组织分化及远处转移无相关性（ P ＞0.05）。（3）癌组织高磷酸化较无磷酸化患者的生存率低，与患者的生存率成负相关（ P ＜0.05）。（4）癌组织标本P－ERK1／2蛋白高磷酸化与无磷酸化患者1a、3a、5a死亡率比较，5a的患者死亡率两者差异有统计学意义（ P ＜0.05）。结论癌组织P－ERK1／2蛋白表达高磷酸化，癌旁正常肠组织几乎无磷酸化；癌组织中P－ERK1／2蛋白表达高磷酸化与患者性别、肿瘤原始发病部位有显著性差异；癌组织P－ERK1／2蛋白高磷酸化与患者生存率呈负相关，P－ERK高磷酸化患者生存时间短、预后差。
目的：研究結直腸腺癌患者MAPK蛋白燐痠化錶達與臨床病理及生存率的相關性。方法收集經病理科診斷、手術切除的原髮結直腸腺癌患者的癌組織標本166例及其癌徬正常組織標本61例。採用免疫組織化學SABC染色方法檢測P－ERK1／2蛋白燐痠化錶達情況，併對病例進行臨床病理資料數據統計和隨訪患者6～60月生存情況。結果（1）結直腸癌患者中61.45％癌組織P－ERK1／2蛋白錶達高燐痠化；98.36％癌徬正常腸組織無燐痠化。（2）癌組織P－ERK1／2蛋白高燐痠化女性較男性患者錶達率高，癌組織原髮部位于結腸的P－ERK1／2蛋白高燐痠化較直腸癌的患者錶達率高，兩者差異有統計學意義（ P ＜0.05）；癌組織P－ERK1／2蛋白燐痠化高錶達與患者年齡、臨床分期、浸潤深度、淋巴轉移、組織分化及遠處轉移無相關性（ P ＞0.05）。（3）癌組織高燐痠化較無燐痠化患者的生存率低，與患者的生存率成負相關（ P ＜0.05）。（4）癌組織標本P－ERK1／2蛋白高燐痠化與無燐痠化患者1a、3a、5a死亡率比較，5a的患者死亡率兩者差異有統計學意義（ P ＜0.05）。結論癌組織P－ERK1／2蛋白錶達高燐痠化，癌徬正常腸組織幾乎無燐痠化；癌組織中P－ERK1／2蛋白錶達高燐痠化與患者性彆、腫瘤原始髮病部位有顯著性差異；癌組織P－ERK1／2蛋白高燐痠化與患者生存率呈負相關，P－ERK高燐痠化患者生存時間短、預後差。
목적：연구결직장선암환자MAPK단백린산화표체여림상병리급생존솔적상관성。방법수집경병이과진단、수술절제적원발결직장선암환자적암조직표본166례급기암방정상조직표본61례。채용면역조직화학SABC염색방법검측P－ERK1／2단백린산화표체정황，병대병례진행림상병리자료수거통계화수방환자6～60월생존정황。결과（1）결직장암환자중61.45％암조직P－ERK1／2단백표체고린산화；98.36％암방정상장조직무린산화。（2）암조직P－ERK1／2단백고린산화녀성교남성환자표체솔고，암조직원발부위우결장적P－ERK1／2단백고린산화교직장암적환자표체솔고，량자차이유통계학의의（ P ＜0.05）；암조직P－ERK1／2단백린산화고표체여환자년령、림상분기、침윤심도、림파전이、조직분화급원처전이무상관성（ P ＞0.05）。（3）암조직고린산화교무린산화환자적생존솔저，여환자적생존솔성부상관（ P ＜0.05）。（4）암조직표본P－ERK1／2단백고린산화여무린산화환자1a、3a、5a사망솔비교，5a적환자사망솔량자차이유통계학의의（ P ＜0.05）。결론암조직P－ERK1／2단백표체고린산화，암방정상장조직궤호무린산화；암조직중P－ERK1／2단백표체고린산화여환자성별、종류원시발병부위유현저성차이；암조직P－ERK1／2단백고린산화여환자생존솔정부상관，P－ERK고린산화환자생존시간단、예후차。
Objective To study the Correlation between the expression of MAPK protein phosphorylation and clinical pathologi -cal and survival rates in colorectal cancer patients.Methods Collected 166 samples of rectal cacer tissues and pararectal cancer tis-sues from affiliated hospitals of Jiamusi University during 2007-2009.The expression of phosphorylated P -ERK1/2 was detected by SABC method.Analysis of clinical pathological data of these patients and follow -up patient ’ s survival status from 6 to 60 months were conducted.The relationship between phosphorylated P -ERK1/2 and clinical pathological characteristics , survival status.Results A-mong colorectal cancer patients , there are 61.4%(102)expressed higher phosphorylated P -ERK1/2, and very few phosphorylated P-ERK1/2 expressed in the para -cancer tissues.The phosphorylated P -ERK1/2 protein in cancer tissues of females is higher than that of males ( P <0.05).The primary cancer which located at colon expressed higher phosphorylated P -ERK1/2 than that located at rectum.The expression of phosphorylated P -ERK1/2has no relationship with age, position, size, clinical stage, lymphatic metas-tasis, differentiation, pathological grade and survival rate ( P >0.05).There are negative relationship between high phosphorylated P-ERK1/2 and survival rate in first year , third year and fifth year ( P <0.05).Conclusion The expression of high phosphorylated P-ERK1/2in rectal cancer has relationship with gender and primary cancer location.The expression of high phosphorylated P -ERK1/2 has negative relationship with survival rate.
