分子诊断与治疗杂志
分子診斷與治療雜誌
분자진단여치료잡지
JOURNAL OF MOLECULAR DIAGNOSIS AND THERAPY
2015年
3期
180-184
,共5页
牙齿缺失%缺血性卒中%预后%改良rankin评分
牙齒缺失%缺血性卒中%預後%改良rankin評分
아치결실%결혈성졸중%예후%개량rankin평분
Tooth loss%Ischemic stroke%Prognosis%Modified rankin scale
目的:探讨牙齿缺失对急性缺血性卒中患者预后的影响。方法选择2011年10月至2012年6月汕头大学医学院附属粤北人民医院神经内科住院的急性期缺血性卒中患者164例,采集患者的人口学资料、既往病史和牙齿缺失等情况,检测血脂、血糖、同型半胱氨酸、超敏C反应蛋白、白细胞、纤维蛋白原、肌酐等血清学指标,入院3天内完成美国国立卫生研究院卒中量表(NIHSS)评分,出院后每半年及研究截止时通过电话随访评定患者改良Rankin量表(mRS)评分。采用t检验或秩和检验比较各组变量指标,组间频率比较采用卡方检验,并行ROC曲线及Logistic回归分析。结果缺血性卒中预后不良相关因素Logistic单因素分析显示,年龄(OR=1.04,95%CI:1.01~1.07, P=0.02)、肌酐(OR=1.01,95%CI:1.00~1.02, P=0.04)、牙齿缺失数(OR=1.05,95%CI:1.01~1.08, P=0.01)及入院时NIHSS评分(OR=1.22,95%CI:1.12~1.33, P<0.001)是预后不良的危险因素。而经Logistic多因素分析,校正年龄及其他因素的影响后,仅NIHSS 评分(OR=1.24,95%CI:1.11~1.40, P<0.001)和牙齿缺失数(OR=1.07,95%CI:1.02~1.12, P=0.004)与缺血性卒中预后不良相关。结论牙齿缺失数可能是与NIHSS评分相同,均是影响缺血性卒中预后不良的危险因素。
目的:探討牙齒缺失對急性缺血性卒中患者預後的影響。方法選擇2011年10月至2012年6月汕頭大學醫學院附屬粵北人民醫院神經內科住院的急性期缺血性卒中患者164例,採集患者的人口學資料、既往病史和牙齒缺失等情況,檢測血脂、血糖、同型半胱氨痠、超敏C反應蛋白、白細胞、纖維蛋白原、肌酐等血清學指標,入院3天內完成美國國立衛生研究院卒中量錶(NIHSS)評分,齣院後每半年及研究截止時通過電話隨訪評定患者改良Rankin量錶(mRS)評分。採用t檢驗或秩和檢驗比較各組變量指標,組間頻率比較採用卡方檢驗,併行ROC麯線及Logistic迴歸分析。結果缺血性卒中預後不良相關因素Logistic單因素分析顯示,年齡(OR=1.04,95%CI:1.01~1.07, P=0.02)、肌酐(OR=1.01,95%CI:1.00~1.02, P=0.04)、牙齒缺失數(OR=1.05,95%CI:1.01~1.08, P=0.01)及入院時NIHSS評分(OR=1.22,95%CI:1.12~1.33, P<0.001)是預後不良的危險因素。而經Logistic多因素分析,校正年齡及其他因素的影響後,僅NIHSS 評分(OR=1.24,95%CI:1.11~1.40, P<0.001)和牙齒缺失數(OR=1.07,95%CI:1.02~1.12, P=0.004)與缺血性卒中預後不良相關。結論牙齒缺失數可能是與NIHSS評分相同,均是影響缺血性卒中預後不良的危險因素。
목적:탐토아치결실대급성결혈성졸중환자예후적영향。방법선택2011년10월지2012년6월산두대학의학원부속월북인민의원신경내과주원적급성기결혈성졸중환자164례,채집환자적인구학자료、기왕병사화아치결실등정황,검측혈지、혈당、동형반광안산、초민C반응단백、백세포、섬유단백원、기항등혈청학지표,입원3천내완성미국국립위생연구원졸중량표(NIHSS)평분,출원후매반년급연구절지시통과전화수방평정환자개량Rankin량표(mRS)평분。채용t검험혹질화검험비교각조변량지표,조간빈솔비교채용잡방검험,병행ROC곡선급Logistic회귀분석。결과결혈성졸중예후불량상관인소Logistic단인소분석현시,년령(OR=1.04,95%CI:1.01~1.07, P=0.02)、기항(OR=1.01,95%CI:1.00~1.02, P=0.04)、아치결실수(OR=1.05,95%CI:1.01~1.08, P=0.01)급입원시NIHSS평분(OR=1.22,95%CI:1.12~1.33, P<0.001)시예후불량적위험인소。이경Logistic다인소분석,교정년령급기타인소적영향후,부NIHSS 평분(OR=1.24,95%CI:1.11~1.40, P<0.001)화아치결실수(OR=1.07,95%CI:1.02~1.12, P=0.004)여결혈성졸중예후불량상관。결론아치결실수가능시여NIHSS평분상동,균시영향결혈성졸중예후불량적위험인소。
Objective To investigate the result of tooth loss effect on the prognosis of acute ischemic stroke. Methods 164 subjects with acute ischemic stroke were recruited. After admission, the general conditions of patients and medical history were collected, as well as the number of missing teeth. The medical fasting blood tests such as lipids, blood glucose, homocysteine, high-sensitivity C-reactive protein, white blood cells, fibrinogen, and creatinine were undertaken within 24 hours. The severity of stroke evaluated with the national institute of health stroke scale (NIHSS) within three days. Modified rankin scale (mRS) was assessed in the form of telephone follow-up when half-year after discharge and at the end of the study. T test, rank sum test and the chi-square test were employed to compare the differences between groups statistically, and logistic regression analysis was employed for the risk factors screening. Results According to the univariate logistic regression, age (OR = 1.04, 95% CI: 1.01 ~1.07, P = 0.02), creatinine (OR = 1.01, 95% CI: 1.00 ~1.02, P =0.04), number of tooth loss (OR=1.05, 95%CI:1.01 ~1.08, P=0.01) and NIHSS score (OR=1.22, 95%CI:1.12 ~ 1.33, P < 0.001) were the risk factors of poor prognosis after stroke. In the multiple logistic regression analysis, number of tooth loss (OR=1.07, 95%CI:1.02 ~1.12, P=0.004) and NIHSS score (OR=1.24, 95%CI:1.11~1.40, P<0.001) were included. Conclusions Both of the number of tooth loss and NIHSS score were the risk factors of poor prognosis after stroke.