CAJ | 학술논문

在临床工作中，随着广谱抗生素的大量使用，伪膜性肠炎（ PMC）的发病率逐年提高。难辨梭状芽孢杆菌是其主要致病菌，通过粪-口途径传播，其主要临床表现为轻重不一的腹泻。 PMC可通过临床症状、实验室检查、内镜检查等手段进行早期诊断，并进行早期积极治疗以预防其反复发作。目前其微生态治疗，尤其是难辨梭状芽孢杆菌疫苗的研制将会成为PMC治疗新的研究方向。
재림상공작중，수착엄보항생소적대량사용，위막성장염（ PMC）적발병솔축년제고。난변사상아포간균시기주요치병균，통과분-구도경전파，기주요림상표현위경중불일적복사。 PMC가통과림상증상、실험실검사、내경검사등수단진행조기진단，병진행조기적겁치료이예방기반복발작。목전기미생태치료，우기시난변사상아포간균역묘적연제장회성위PMC치료신적연구방향。
Due to the massive use of broad-spectrum antibiotics in clinic,the incidence of pseudomen-braneouscolitis( PMC) has increased dramatically.Clostridium difficile is the main pathogenic bacteria of PMC,that it is infected through the fecal-oral route,with main clinical manifestation of different levels of diar-rhea.Pseudomenbraneouscloitis can be early diagnosed by clinical symptoms,laboratory examination and endoscope.And early treatment can prevent recurrence of PMC.Recently,microecologic therapy especially the development of vaccine of clostridium difficile will become new research direction in the treatment for PMC .