CAJ | 학술논문

目的：优选治前胶囊的提取工艺,为将该制剂开发成中药新药提供依据。方法以浸泡时间、加水量、提取时间为主要影响因素,以浸膏得率和秦皮乙素浸出量为评价指标,采用单因素试验和星点设计-效应面法优选治前胶囊的最佳提取工艺。结果优选的最佳提取工艺条件为：回流提取2次,第1次加10倍量水、提取2.5 h,第2次加8倍量水、提取2 h。结论优选的最佳提取工艺条件对秦皮乙素提取效率高,经济、合理、简单可行。
목적：우선치전효낭적제취공예,위장해제제개발성중약신약제공의거。방법이침포시간、가수량、제취시간위주요영향인소,이침고득솔화진피을소침출량위평개지표,채용단인소시험화성점설계-효응면법우선치전효낭적최가제취공예。결과우선적최가제취공예조건위：회류제취2차,제1차가10배량수、제취2.5 h,제2차가8배량수、제취2 h。결론우선적최가제취공예조건대진피을소제취효솔고,경제、합리、간단가행。
Objective To optimize the extraction technology of Zhiqian Capsule;To provide evidence for researches on preparation into new Chinese medicine. Methods The main influential factors of extraction technology included the quantity of water, extraction time and immersion time. The extraction effect was evaluated with the content of aesculetin and the extract yield as indexes. The optimal extraction technology of Zhiqian Capsule was selected by single factor experiment and central composite design-response surface method. Results The best extraction conditions were as follows:reflux extraction for twice, the first time adding 10-fold of water and extraction for 2.5 h, the second time adding 8-fold of water and extraction for 2 h. Conclusion The optimal extraction technology of Zhiqian Capsule is efficient for extracting aesculetin, as well as economical, reasonable, easy and feasible.