中国中医药信息杂志
中國中醫藥信息雜誌
중국중의약신식잡지
CHINESE JOURNAL OF INFORMATION ON TRADITIONAL CHINESE MEDICINE
2015年
6期
50-53
,共4页
肿瘤%名医经验%用药分析%关联规则%聚类算法
腫瘤%名醫經驗%用藥分析%關聯規則%聚類算法
종류%명의경험%용약분석%관련규칙%취류산법
phymatosis%famous doctors experience%analysis of drug use%association rules%clustering algorithm
目的：探讨国家级名老中医治疗肿瘤的用药规律。方法收集国家级名老中医治疗肿瘤处方，采用关联规则apriori算法和复杂系统熵聚类方法，确定处方中各单味药物频次、药物组合频次、药物之间的关联规则和核心组合等。结果高频药物包括黄芪、半夏、茯苓、白花蛇舌草、生地黄等；高频药物组合包括“白术，茯苓”“陈皮，茯苓”“白术，党参”“茯苓，党参”等；置信度为1的关联规则包括“三棱→莪术”“牡丹皮，桃仁→赤芍”等；新处方包括“莪术，三棱，穿山甲，夏枯草，续断”“重楼，沙参，皂角刺，海藻，昆布”等。结论名老中医治疗肿瘤处方多用补脾益气、清热解毒、活血化瘀之品，符合中医标本兼治之用药原则。
目的：探討國傢級名老中醫治療腫瘤的用藥規律。方法收集國傢級名老中醫治療腫瘤處方，採用關聯規則apriori算法和複雜繫統熵聚類方法，確定處方中各單味藥物頻次、藥物組閤頻次、藥物之間的關聯規則和覈心組閤等。結果高頻藥物包括黃芪、半夏、茯苓、白花蛇舌草、生地黃等；高頻藥物組閤包括“白術，茯苓”“陳皮，茯苓”“白術，黨參”“茯苓，黨參”等；置信度為1的關聯規則包括“三稜→莪術”“牡丹皮，桃仁→赤芍”等；新處方包括“莪術，三稜，穿山甲，夏枯草，續斷”“重樓，沙參，皂角刺，海藻，昆佈”等。結論名老中醫治療腫瘤處方多用補脾益氣、清熱解毒、活血化瘀之品，符閤中醫標本兼治之用藥原則。
목적：탐토국가급명로중의치료종류적용약규률。방법수집국가급명로중의치료종류처방，채용관련규칙apriori산법화복잡계통적취류방법，학정처방중각단미약물빈차、약물조합빈차、약물지간적관련규칙화핵심조합등。결과고빈약물포괄황기、반하、복령、백화사설초、생지황등；고빈약물조합포괄“백술，복령”“진피，복령”“백술，당삼”“복령，당삼”등；치신도위1적관련규칙포괄“삼릉→아술”“모단피，도인→적작”등；신처방포괄“아술，삼릉，천산갑，하고초，속단”“중루，사삼，조각자，해조，곤포”등。결론명로중의치료종류처방다용보비익기、청열해독、활혈화어지품，부합중의표본겸치지용약원칙。
Objective To explore the medication rules of national TCM masters’ treatment for phymatosis. Methods The prescriptions for phymatosis of national TCM masters were collected to build a database. The methods of association rules with apriori algorithm and complex system entropy cluster were used to achieve frequency of individual herbs, frequency of medicine combinations, association rules of herbs and core medicine combinations. Results In the prescriptions for phymatosis, Chinese medicinal herbs with the highest frequency were Astragali Radix, Pinelliae Rhizoma, Poria, Herba Oldenlandiae, Rehmanniae Radix Exsiccata, and so on. Medicine combinations with the highest frequencywere Atractylodis Macrocephalae Rhizoma-Poria, Citri Reticulatae Pericarpium-Poria, Atractylodis Macrocephalae Rhizoma-Codonopsis Radix, and Poria-Codonopsis Radix. The medicine association rules of confidence coefficient 1 were Sparganii Rhizoma→Curcumae Rhizoma, and Moutan Cortex, Persicae Semen→Paeoniae Radix Rubra. The new prescriptions composited by “Curcumae Rhizoma, Sparganii Rhizoma, Manis Squama, Prunella Spica, Dipsacus Asperoides”, or “Paridis Rhizoma, Adenophorae Radix, Gleditsiae Spina, Sargassum, Laminariae Thallus”. Conclusions Chinese medicinal herbs used in the prescriptions of national TCM masters for the treatment of phymatosis were often with the actions of invigorating the spleen and benefiting qi, clearing away heat and toxic material, and promoting blood circulation to remove blood stasis, which were complied with the medication rule of treating both the incidental and fundamental aspects in TCM.
