CAJ | 학술논문

【目的】探讨H型高血压患者血清同型半胱氨酸（Hcy ）水平变化的相关因素。【方法】选择2013年5月至2014年9月在本院就诊的血清 Hcy≥10μmol／L高血压患者286例，根据Hcy水平分为轻度组140例和重度组146例，对照组73例，收集三组样本临床资料及生化指标。分析Hcy水平变化与亚临床靶器官损害指标之间的相关性。【结果】H型高血压组患者的年龄，Hcy、血肌酐（Cr）、血尿酸（UA）、尿微量白蛋白（UmAlb）、颈总动脉内膜中层厚度（IM T ）、斑块检出率水平明显高于对照组，重度组高于轻度组；维生素B12、叶酸、血压昼夜节律水平明显低于对照组，重度组低于轻度组，差异均有统计学意义（均 P＜0．05）。Hcy与血压昼夜节律、维生素B12、叶酸呈负相关（ P ＜0．05）；Hcy与年龄、24 h平均收缩压（24hSBP）、Cr、UA、IMT、UmAlb呈正相关（ P ＜0．05）。【结论】H型高血压患者血清 Hcy水平变化与亚临床靶器官损害指标之间密切相关。
【목적】탐토H형고혈압환자혈청동형반광안산（Hcy ）수평변화적상관인소。【방법】선택2013년5월지2014년9월재본원취진적혈청 Hcy≥10μmol／L고혈압환자286례，근거Hcy수평분위경도조140례화중도조146례，대조조73례，수집삼조양본림상자료급생화지표。분석Hcy수평변화여아림상파기관손해지표지간적상관성。【결과】H형고혈압조환자적년령，Hcy、혈기항（Cr）、혈뇨산（UA）、뇨미량백단백（UmAlb）、경총동맥내막중층후도（IM T ）、반괴검출솔수평명현고우대조조，중도조고우경도조；유생소B12、협산、혈압주야절률수평명현저우대조조，중도조저우경도조，차이균유통계학의의（균 P＜0．05）。Hcy여혈압주야절률、유생소B12、협산정부상관（ P ＜0．05）；Hcy여년령、24 h평균수축압（24hSBP）、Cr、UA、IMT、UmAlb정정상관（ P ＜0．05）。【결론】H형고혈압환자혈청 Hcy수평변화여아림상파기관손해지표지간밀절상관。
[Objective]To explore the relationship between the serum level of homocysteine (Hcy) and subclinical damage of cardiovascular target organ in H type hypertension .[Methods] A total of 286 patients with H type hypertension and 73 controls without hypertension were recruited .According to the Hcy level ,H type hypertensive patients (HTH group) were divided into mild ( n = 140) and severe ( n =146) groups . General clinical data and relevant biochemical parameters were analyzed .[Results] (1)Age ,creatinine (Cr) , uricacid (UA),urinary microalbumin (UMALB),intimal media thickness (IMT) and detection rate of plaques were all higher in HTH group than those in control group and higher in severe group than those in mild group ( P<0 .05) .Vitamin B12 ,folic acid and circadian rhythm of blood pressure were all lower in HTH and severe groups ( P <0 .05) .Pearson's correlation analysis showed that there were negative relationships between serum Hcy and circadian rhythm of blood pressure ,serum levels of vitamin B12 and folic acid .And there were positive relationships between serum Hcy and age ,24hSBP ,Cr ,UA ,IMT and UMALB .[Conclu‐sion]The serum level of Hcy is closely correlated with subclinical damage of cardiovascular target organ in H type hypertension .