CAJ | 학술논문

目的探讨乙型肝炎患者外周血体液免疫功能状况和血清IFN-γ、TNF-α变化与疾病转归关系.方法采用散射比浊法检测352例乙肝病毒性肝炎患者血清IgG、IgA、IgM和C3、C4水平.结果不同HBV-DNA载量、急性或亚急性肝衰竭组和HBV慢性感染组HBV患者血清IgG、IgA、IgM水平较正常对照组则升高(P＜0.05),而C3、C4水平较正常对照组均降低(P＜0.05);急性白限性HBV组和隐匿性HBV组血清IgG、IgA、IgM及C3、C4水平与正常对照组比较差异无统计学意义(P＞0.05):HBc-IgM阳性患者经IFN-α治疗6个月后C3、C4水平有明显提高,血清IgG、IgA、IgM趋向正常,HBV-DNA阴转率达37.5％,与基础治疗组比较差异有统计学意义(P＜0.05).结论乙肝患者存在体液免疫功能紊乱,体液免疫功能状况与HBV的临床转归存在一定的相关性,其检测对乙肝的诊断、治疗及预后的判断有着一定临床意义.
목적 탐토을형간염환자외주혈체액면역공능상황화혈청IFN-γ、TNF-α변화여질병전귀관계.방법 채용산사비탁법검측352례을간병독성간염환자혈청IgG、IgA、IgM화C3、C4수평.결과 불동HBV-DNA재량、급성혹아급성간쇠갈조화HBV만성감염조HBV환자혈청IgG、IgA、IgM수평교정상대조조칙승고(P＜0.05),이C3、C4수평교정상대조조균강저(P＜0.05);급성백한성HBV조화은닉성HBV조혈청IgG、IgA、IgM급C3、C4수평여정상대조조비교차이무통계학의의(P＞0.05):HBc-IgM양성환자경IFN-α치료6개월후C3、C4수평유명현제고,혈청IgG、IgA、IgM추향정상,HBV-DNA음전솔체37.5％,여기출치료조비교차이유통계학의의(P＜0.05).결론 을간환자존재체액면역공능문란,체액면역공능상황여HBV적림상전귀존재일정적상관성,기검측대을간적진단、치료급예후적판단유착일정림상의의.
Objective To explore the correlation of the organism humoral immune function situation and the changes of serum IFN-γ and TNF-α with the clinical prognosis in HBV patients.Methods Scattering nephelometry was used to detect the serum levels of IgG,IgA,IgM,C3,and C4 in 352 HBV patients.The level sof serum IFN-γ and TNF-α were detected by ELISA.82 healthy subjects were chosen as controls.Results The levels of IgG,IgA and IgM of the patients with different DNA capacities,acute or subacute liver failure,or chronic HBV infection HBV were higher than those of the controls (P＜0.05) while the serum levels of C3 and C4 were lower than those of the controls (P＜0.05).The levels of IgG,IgA,IgM,C3,and C4 of the patients with acute self-limited HBV or occult HBV were not statistically different from those of the controls (P＞0.05).After IFN-α treatment for six months,the HBc-IgM positive HBV patients'C3 and C4 levels were significantly increased.IgG,IgA,and IgM levels were getting normal,and the HBV-DNA negative rate was 37.5％,with no statistical difference from basic treatment (P＜0.05).Conclusions Patients with HBV have the disorder of humoral immunity.Humoral immune function situation correlates with the clinical prognosis of patients with HBV.Detecting Humoral immune function plays an important role in HBV patients' diagnosis,treatment,and prognosis.