国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2015年
9期
1196-1198
,共3页
慢性心力衰竭%白细胞介素-17%白细胞介素-10
慢性心力衰竭%白細胞介素-17%白細胞介素-10
만성심력쇠갈%백세포개소-17%백세포개소-10
Chronic heart failure%Interleukin-17%Interleukin-10
目的 探讨慢性心力衰竭与白细胞介素(IL)-17、IL-10的相关性.方法 采用酶联免疫吸附试验(ELISA)检测37例慢性心力衰竭患者(慢性心衰组)和34例健康体检者(对照组)血浆IL-17和IL-10水平,并进行相关性分析.结果 慢性心衰组血浆IL-17水平高于对照组[(46.37±10.57) ng/L vs(32.45±4.55)ng/L],IL-10水平低于对照组[(27.49±4.19) ng/L vs(32.71±4.38) ng/L],差异均有统计学意义(t=7.09,5.46,P＜0.01);慢性心力衰竭患者血浆IL-17与IL-10呈负相关(r=-0.63,P＜0.01).结论 慢性心力衰竭的发病可能与体内IL-17、IL-10的水平失衡存在相关.
目的 探討慢性心力衰竭與白細胞介素(IL)-17、IL-10的相關性.方法 採用酶聯免疫吸附試驗(ELISA)檢測37例慢性心力衰竭患者(慢性心衰組)和34例健康體檢者(對照組)血漿IL-17和IL-10水平,併進行相關性分析.結果 慢性心衰組血漿IL-17水平高于對照組[(46.37±10.57) ng/L vs(32.45±4.55)ng/L],IL-10水平低于對照組[(27.49±4.19) ng/L vs(32.71±4.38) ng/L],差異均有統計學意義(t=7.09,5.46,P＜0.01);慢性心力衰竭患者血漿IL-17與IL-10呈負相關(r=-0.63,P＜0.01).結論 慢性心力衰竭的髮病可能與體內IL-17、IL-10的水平失衡存在相關.
목적 탐토만성심력쇠갈여백세포개소(IL)-17、IL-10적상관성.방법 채용매련면역흡부시험(ELISA)검측37례만성심력쇠갈환자(만성심쇠조)화34례건강체검자(대조조)혈장IL-17화IL-10수평,병진행상관성분석.결과 만성심쇠조혈장IL-17수평고우대조조[(46.37±10.57) ng/L vs(32.45±4.55)ng/L],IL-10수평저우대조조[(27.49±4.19) ng/L vs(32.71±4.38) ng/L],차이균유통계학의의(t=7.09,5.46,P＜0.01);만성심력쇠갈환자혈장IL-17여IL-10정부상관(r=-0.63,P＜0.01).결론 만성심력쇠갈적발병가능여체내IL-17、IL-10적수평실형존재상관.
Objective To investigate the correlation between chronic heart failure and the levels of IL-17 and IL-10.Methods The levels of IL-17 and IL-10 was measured by enzyme-linked immunosorbent assay (ELISA) in 37 patients with chronic heart failure (chronic heart failure group) and 34 normal controls(control group).The correlation between chronic heart failure and the levels of IL-17 and IL-10.Results The level of IL-17 was higher and the level of IL-10 was lower in the chronic heart failure group than that in the control group[(46.37±10.57)ng/L vs.(32.45±4.55) ng/L,t=7.09,P＜0.01;(27.49±4.19)ng/L vs.(32.71±4.38)ng/L,t=5.46,P＜0.01],with statistical differences.There was negative correlation between IL-17 and IL-10 in patients with chronic heart failure (r=-0.63.P＜0.01).Conclusions The pathogenesis of chronic heart failure may relate to the imbalance of IL-17and IL-10.
