CAJ | 학술논문

【目的】探讨乳腺癌内分泌治疗失败的原因，为制订临床治疗方案提供参考。【方法】选取2011年1月至2013年12月确诊为乳腺癌并在本院治疗的62例患者的临床资料进行回顾性分析。所有患者术后均行相同方案的内分泌治疗而失败，观察并总结失败的发生率和原因，并进行统计学分析。【结果】62例患者中20例治疗失败，发生率为32．3％。年龄＞45岁、绝经后、表皮生长因子受体‐2（HER‐2）、雌激素受体（ER）磷酸化抗体阳性和类固醇受体辅助活化因子（SRC）表达阳性患者治疗失败率明显升高（ P ＜0．05）。【结论】年龄、绝经、HER‐2、ER磷酸化抗体阳性和SRC表达与乳腺癌内分泌治疗效果有明显的相关性。
【목적】탐토유선암내분비치료실패적원인，위제정림상치료방안제공삼고。【방법】선취2011년1월지2013년12월학진위유선암병재본원치료적62례환자적림상자료진행회고성분석。소유환자술후균행상동방안적내분비치료이실패，관찰병총결실패적발생솔화원인，병진행통계학분석。【결과】62례환자중20례치료실패，발생솔위32．3％。년령＞45세、절경후、표피생장인자수체‐2（HER‐2）、자격소수체（ER）린산화항체양성화류고순수체보조활화인자（SRC）표체양성환자치료실패솔명현승고（ P ＜0．05）。【결론】년령、절경、HER‐2、ER린산화항체양성화SRC표체여유선암내분비치료효과유명현적상관성。
[Objective] To explore the reasons for a failure of endocrine therapy for breast cancer and pro‐vide rationales for clinical therapeutics .[Methods] From January 2008 to December 2010 ,the clinical data were retrospectively analyzed for 62 cases of breast cancer at our hospital .They received the same scheme of failed endocrine therapy .And the incidence and causes of failure were observed ,summarized and statistically analyzed .[Results] The incidence of failure was 32 .3% .Age >45 years ,postmenopause ,epidermal growth factor receptor‐2 (HER‐2) ,positive phosphorylation of estrogen receptor (ER) antibody and steroid receptor coactivator (SRC) were associated with a significantly elevated rate of treatment failure ( P<0 .05) .[Conclu‐sion] Age ,menopause ,HER‐2 ,positive phosphorylation of ER antibody and SRC are significantly associated with the outcomes of breast cancer endocrine therapy .