医学临床研究
醫學臨床研究
의학림상연구
JOURNAL OF CLINICAL RESEARCH
2015年
4期
665-667
,共3页
黎赛%周舟%胡彬%易苏武%肖政辉%罗俊明
黎賽%週舟%鬍彬%易囌武%肖政輝%囉俊明
려새%주주%호빈%역소무%초정휘%라준명
利钠肽,脑/血液%参考值%儿童%荧光免疫测定
利鈉肽,腦/血液%參攷值%兒童%熒光免疫測定
리납태,뇌/혈액%삼고치%인동%형광면역측정
Natriuretic Peptide,Brain/BL%Reference Values%Child%Fluoroimmunoassay
【目的】建立0~18岁健康人群血清N末端脑钠肽前体(N terminal pro‐brain natriuretic peptide ,NT‐proBNP)参考值范围。【方法】用免疫荧光法检测1225例0~18岁健康人群的血清NT‐proBNP浓度。【结果】1225例儿童按新生儿期(0~30 d )、婴儿期(1个月至1岁)、幼儿期(1~4岁)、学龄前期(4~7岁)、学龄初期(7~10岁)、学龄中期(10~13岁)、青春期(13~18岁)年龄分组检测血清 NT‐proBNP水平,结果依次为:中位数1360.0 pg/mL ,参考范围(250.0~3987.0) pg/mL ;中位数106.0 pg/mL ,参考范围(20.0~532.0) pg/mL ;中位数80.0 pg/mL ,参考范围(20.0~324.0) pg/mL ;中位数58.0 pg/mL ,参考范围(20.0~374.0) pg/mL ;中位数38.0 pg/mL ,参考范围(20.0~163.0) pg/mL ;中位数29.0 pg/mL ,参考范围(20.0~296.0) pg/mL ;中位数20.0 pg/mL ,参考范围(20.0~145.0) pg/mL。0~18岁健康人群各年龄组NT‐proBNP水平与年龄的增长呈负相关(R=-0.230,P<0.05)。各年龄段男女性别间的NT‐proBNP无显著性差异( P>0.05)。【结论】0~18岁健康人群血清NT‐proBNP水平随年龄增加有降低趋势;0~18岁不同年龄段健康人群血清NT‐proBNP参考值范围与成人不同,不能随意套用。
【目的】建立0~18歲健康人群血清N末耑腦鈉肽前體(N terminal pro‐brain natriuretic peptide ,NT‐proBNP)參攷值範圍。【方法】用免疫熒光法檢測1225例0~18歲健康人群的血清NT‐proBNP濃度。【結果】1225例兒童按新生兒期(0~30 d )、嬰兒期(1箇月至1歲)、幼兒期(1~4歲)、學齡前期(4~7歲)、學齡初期(7~10歲)、學齡中期(10~13歲)、青春期(13~18歲)年齡分組檢測血清 NT‐proBNP水平,結果依次為:中位數1360.0 pg/mL ,參攷範圍(250.0~3987.0) pg/mL ;中位數106.0 pg/mL ,參攷範圍(20.0~532.0) pg/mL ;中位數80.0 pg/mL ,參攷範圍(20.0~324.0) pg/mL ;中位數58.0 pg/mL ,參攷範圍(20.0~374.0) pg/mL ;中位數38.0 pg/mL ,參攷範圍(20.0~163.0) pg/mL ;中位數29.0 pg/mL ,參攷範圍(20.0~296.0) pg/mL ;中位數20.0 pg/mL ,參攷範圍(20.0~145.0) pg/mL。0~18歲健康人群各年齡組NT‐proBNP水平與年齡的增長呈負相關(R=-0.230,P<0.05)。各年齡段男女性彆間的NT‐proBNP無顯著性差異( P>0.05)。【結論】0~18歲健康人群血清NT‐proBNP水平隨年齡增加有降低趨勢;0~18歲不同年齡段健康人群血清NT‐proBNP參攷值範圍與成人不同,不能隨意套用。
【목적】건립0~18세건강인군혈청N말단뇌납태전체(N terminal pro‐brain natriuretic peptide ,NT‐proBNP)삼고치범위。【방법】용면역형광법검측1225례0~18세건강인군적혈청NT‐proBNP농도。【결과】1225례인동안신생인기(0~30 d )、영인기(1개월지1세)、유인기(1~4세)、학령전기(4~7세)、학령초기(7~10세)、학령중기(10~13세)、청춘기(13~18세)년령분조검측혈청 NT‐proBNP수평,결과의차위:중위수1360.0 pg/mL ,삼고범위(250.0~3987.0) pg/mL ;중위수106.0 pg/mL ,삼고범위(20.0~532.0) pg/mL ;중위수80.0 pg/mL ,삼고범위(20.0~324.0) pg/mL ;중위수58.0 pg/mL ,삼고범위(20.0~374.0) pg/mL ;중위수38.0 pg/mL ,삼고범위(20.0~163.0) pg/mL ;중위수29.0 pg/mL ,삼고범위(20.0~296.0) pg/mL ;중위수20.0 pg/mL ,삼고범위(20.0~145.0) pg/mL。0~18세건강인군각년령조NT‐proBNP수평여년령적증장정부상관(R=-0.230,P<0.05)。각년령단남녀성별간적NT‐proBNP무현저성차이( P>0.05)。【결론】0~18세건강인군혈청NT‐proBNP수평수년령증가유강저추세;0~18세불동년령단건강인군혈청NT‐proBNP삼고치범위여성인불동,불능수의투용。
[Objective] To establish reference range for serum N‐terminal‐proBNP (NT‐proBNP) in children aged 0~18 years .[Methods] Serum NT‐proBNP was detected by immunofluorescence assay in a total of 1225 children .[Results] They were divided into 7 groups by age ,i .e .neonatal period (0‐<1 month) ,infant period (1 month‐<1 year) ,toddler period (1 year‐<4 years) ,preschool (4‐<7 years) ,early school (7‐<10 years) , middle school (10‐<13 years ) and adolescence (13‐<18 years) .The median and reference range for serum NT‐proBNP in them were 1360 .0 (250 .0~3987 .0) ,106 .0 (20 .0~532 .0) ,80 .0(20 .0~324 .0) ,58 .0 (20 .0~374 . 0) ,38 .0(20 .0~163 .0) ,29 .0 (20 .0~296 .0) and 20 .0(20 .0~145 .0) pg/mL respectively .The relationship of serum NT‐proBNP and age had a negative correlation (R= -0 .230 ,P<0 .05) .No significant differences existed between girls and boys ( P <0 .05) .[Conclusion] The serum level of NT‐proBNP shows a declining trend with advancing age in children .Normal reference ranges of NT‐proBNP for children at different ages vary from those of adults .