CAJ | 학술논문

目的：分析补益类中药临床应用不良反应发生情况。方法检索中国知识资源总库(CNKI)、中文科技期刊全文数据库(VIP)、中国生物医学文献数据库(CBM)、Pubmed和Embase中1990年1月－2014年2月收录的补益类中药药物不良反应(ADR)相关文献，按纳入与排除标准选择文献、提取资料，并进行计量学分析。结果在378篇ADR报道中，最易引起ADR的补益类单味中药为何首乌、人参、枸杞子、黄芪，注射剂类分别为参麦注射液、生脉注射液、刺五加注射液，而其他中药制剂则以首乌片为最；ADR累及组织或系统方面，以皮肤组织、神经系统、消化系统损害常见，其相应临床症状以瘙痒、皮疹、头晕、意识不清、呕吐、恶心、肝功能异常为主。结论正确认识补益类中药的不良反应，有助于临床合理用药，规避风险。
목적：분석보익류중약림상응용불량반응발생정황。방법검색중국지식자원총고(CNKI)、중문과기기간전문수거고(VIP)、중국생물의학문헌수거고(CBM)、Pubmed화Embase중1990년1월－2014년2월수록적보익류중약약물불량반응(ADR)상관문헌，안납입여배제표준선택문헌、제취자료，병진행계량학분석。결과재378편ADR보도중，최역인기ADR적보익류단미중약위하수오、인삼、구기자、황기，주사제류분별위삼맥주사액、생맥주사액、자오가주사액，이기타중약제제칙이수오편위최；ADR루급조직혹계통방면，이피부조직、신경계통、소화계통손해상견，기상응림상증상이소양、피진、두훈、의식불청、구토、악심、간공능이상위주。결론정학인식보익류중약적불량반응，유조우림상합리용약，규피풍험。
Objective To analyze the occurrence of clinical adverse drug reaction (ADR) of tonic Chinese medicinal herbs. Methods Articles about ADR of tonic Chinese medicinal herbs reported from January 1990 to February 2014 were collected from databases of CNKI, VIP, CBM, Pubmed and Embase according to incorporation and exclusion standard. Metrology analysis was also conducted. Results Totally 378 effective articles showed tonic Chinese medicinal herbs most likely to induce ADR were as follows:individual Chinese medicinal herbs including Polygoni Multiflori Radix, Ginseng Radix et Rhizoma, Lycii Fructus and Astragali Radix;injection containing Shenmai Injection, Shengmai Injection and Acanthopanax Injection;other herbal preparation covering Polygoni Multiflori tablets. The most common ADR involved the damage on skin tissue, nervous system and digestive system, with prominent relevant clinical symptoms such as itching, skin rash, dizziness, unconsciousness, nausea, vomiting, and liver dysfunction. Conclusion Correct understanding adverse reaction of tonic Chinese medicinal herbs will be conducive to rational drug use and avoiding risk.