CAJ | 학술논문

目的：观察仙鹤草降糖散治疗2型糖尿病(T2DM)的临床效果。方法选取本院2012年6月~2014年5月收治的120例符合诊断标准的T2DM患者，将患者按照随机数字表法随机分成实验组、对照A组、对照B组，各40例。实验组采用仙鹤草降糖散治疗，对照A组口服格列本脲，加服六味地黄丸治疗，对照B组口服格列本脲。观察3组患者的空腹血糖(FPG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)，糖尿病并发症(糖尿病足溃疡、视网膜病变、动脉硬化闭塞症、末梢神经病变、糖尿病肾病)以及临床效果。结果实验组治疗后的FPG、2 h PG、HbA1c、TC、TG、HDL-C、LDL-C与治疗前比较，差异有统计学意义(P<0.01)。对照A组除TG外，其他指标与治疗前比较，差异有统计学意义(P<0.05或P<0.01)；对照B组除FPG、HbA1c、TG、HDL-C外，其他指标与治疗前比较，差异有统计学意义(P<0.01或P<0.05)。治疗后3组比较，除TG外，其余指标比较，差异有统计学意义(P<0.01或P<0.05)。实验组的并发症发生率虽然比其他两组低，但差异无统计学意义(P>0.05)。实验组的总有效率为92.50%，对照A组为67.50%，对照B组为75.00%，3组的临床疗效比较，差异有统计学意义(χ2=9.128，P<0.05)。结论仙鹤草降糖散适合治疗2型糖尿病，且并发症发生率较低，值得临床进一步推广。
목적：관찰선학초강당산치료2형당뇨병(T2DM)적림상효과。방법선취본원2012년6월~2014년5월수치적120례부합진단표준적T2DM환자，장환자안조수궤수자표법수궤분성실험조、대조A조、대조B조，각40례。실험조채용선학초강당산치료，대조A조구복격렬본뇨，가복륙미지황환치료，대조B조구복격렬본뇨。관찰3조환자적공복혈당(FPG)、찬후2 h혈당(2 h PG)、당화혈홍단백(HbA1c)、총담고순(TC)、삼선감유(TG)、고밀도지단백담고순(HDL-C)、저밀도지단백담고순(LDL-C)，당뇨병병발증(당뇨병족궤양、시망막병변、동맥경화폐새증、말소신경병변、당뇨병신병)이급림상효과。결과실험조치료후적FPG、2 h PG、HbA1c、TC、TG、HDL-C、LDL-C여치료전비교，차이유통계학의의(P<0.01)。대조A조제TG외，기타지표여치료전비교，차이유통계학의의(P<0.05혹P<0.01)；대조B조제FPG、HbA1c、TG、HDL-C외，기타지표여치료전비교，차이유통계학의의(P<0.01혹P<0.05)。치료후3조비교，제TG외，기여지표비교，차이유통계학의의(P<0.01혹P<0.05)。실험조적병발증발생솔수연비기타량조저，단차이무통계학의의(P>0.05)。실험조적총유효솔위92.50%，대조A조위67.50%，대조B조위75.00%，3조적림상료효비교，차이유통계학의의(χ2=9.128，P<0.05)。결론선학초강당산괄합치료2형당뇨병，차병발증발생솔교저，치득림상진일보추엄。
Objective To investigate the clinical effect of Agrimony hypoglycemic powder treating type 2 diabetes (T2DM). Methods 120 patients with T2DM accordance with the diagnostic criteria treated in our hospital from June 2012 to May 2014 were selected and randomly divided into experimental group (n=40),control group A (n=40) and con-trol group B (n=40) according to the random number table method. Experimental group was treated with Agrimony hy-poglycemic powder,while control group A was treated with oral glibenclamide and Liuwei Dihuang pill,control group B was treated with oral glibenclamide,Fasting plasma glucose (FPG),2 h postprandial glucose (2 h PG),glycated hemoglobin (HbA1c),total cholesterol (TC),triglyceride (TG),high density lipoprotein cholesterol (HDL-C),low density lipoprotein cholesterol (LDL-C) were observed and diabetic complications (diabetic foot ulcer,retinopathy, arteriosclero-sis obliterans,peripheral neuropathy,diabetic nephropathy),and the clinical effect were observed of three groups. Results There was a statistical difference of FPG,2 h PG,HbA1c,TC,TG,HDL-C,LDL-C after treatment compared with before treatment (P<0.01).Except for TG in control group A,there was a statistical difference of other indexes after treatment compared with before treatment (P<0.05 or P<0.01).Except for FPG,HbA1c,TG,HDL-C in control group B,there was a statistical difference of other indexes after treatment compared with before treatment (P<0.01 or P<0.05).Except for TG, there was a statistical difference of other indexes after treatment among three groups (P<0.01 or P<0.05).Incidence rate of complication in experimental group was lower than that of the other two groups,but did not show statistically differ-ence (P>0.05).The total effective rate of experimental group was 92.50%,and it was 67.50% in control group A,it was 75.00% in control group B,and there was a statistical difference of the total effective rate among three groups (χ2=9.128,P<0.05). Conclusion Agrimony hypoglycemic powder treating T2DM is suitable with lower the incidence rate of complication.It is worthy of further promotion in clinic.