CAJ | 학술논문

【目的】探讨细胞外基质金属蛋白酶诱导因子（CD147）和基质金属蛋白酶2（MMP‐2）在胆囊癌组织中的表达及意义。【方法】采用免疫组织化学法检测30例慢性胆囊炎和21例胆囊癌患者组织中CD147和M M P‐2的表达，并分析其临床意义。【结果】21例胆囊癌组织中 CD147和 M M P‐2的阳性表达率分别为71．4％（15／21）和76．2％（16／21），显著高于慢性胆囊炎组织中的表达13．3％（4／30）和23．3％（7／30）（ P ＜0．01）；CD147和M M P‐2的阳性表达与胆囊癌的临床分期和淋巴结转移显著相关（ P ＜0．05），且胆囊癌中CD147与MMP‐2的阳性表达呈正相关（ r ＝0．631，P ＝0．002）。【结论】CD147和MMP‐2在胆囊癌组织中的阳性表达与其临床分期和淋巴结转移相关，CD147可能通过与M M P‐2的相互作用共同参与调控胆囊癌的进展与转移。
【목적】탐토세포외기질금속단백매유도인자（CD147）화기질금속단백매2（MMP‐2）재담낭암조직중적표체급의의。【방법】채용면역조직화학법검측30례만성담낭염화21례담낭암환자조직중CD147화M M P‐2적표체，병분석기림상의의。【결과】21례담낭암조직중 CD147화 M M P‐2적양성표체솔분별위71．4％（15／21）화76．2％（16／21），현저고우만성담낭염조직중적표체13．3％（4／30）화23．3％（7／30）（ P ＜0．01）；CD147화M M P‐2적양성표체여담낭암적림상분기화림파결전이현저상관（ P ＜0．05），차담낭암중CD147여MMP‐2적양성표체정정상관（ r ＝0．631，P ＝0．002）。【결론】CD147화MMP‐2재담낭암조직중적양성표체여기림상분기화림파결전이상관，CD147가능통과여M M P‐2적상호작용공동삼여조공담낭암적진전여전이。
[Objective] To explore the expressions of CD147 and matrix metalloprotease‐2 (MMP‐2) in tissues of chronic cholecystitis and gallbladder carcinoma and examine their clinical significance .[Methods]Immunohistochemistry was used for detecting CD147 and MMP‐2 in 30 chronic cholecystitis tissues and 21 gallbladder carcinoma tissues .And their clinicopathological data were analyzed .[Results] The expressions of CD147 and MMP‐2 was significant higher in 21 gallbladder carcinoma tissues [71 .4% (15/21)& 76 .2% (16/21)] than those in 30 chronic cholecystitis tissues [13 .3% (4/30)& 23 .3% (7/30)]( P<0 .01) .And the pos‐itive expressions of both were correlated with staging and lymph node metastasis ( P<0 .05) .The expressions of CD147 and MMP‐2 had a positive correlation in gallbladder carcinoma ( r =0 .631 ,P =0 .002) .[Conclu‐sion] The expressions of CD147 and MMP‐2 are positively correlated with staging and lymph node metastasis in gallbladder carcinoma .And CD147 may interact with MMP‐2 in regulating the progression of gallbladder carcinoma .