CAJ | 학술논문

【目的】探讨鼠神经生长因子对糖尿病周围神经病变的临床治疗效果。【方法】选择本院2012年3月至2014年2月收治的82例糖尿病周围神经病变患者为研究对象，随机分为对照组与观察组，每组41例患者，对照组采取甲钴胺注射液治疗，观察组行鼠神经生长因子肌肉注射治疗，对两组患者治疗前后的血压、血脂、血糖水平进行分析，并观察比较两组患者治疗前后睡眠质量评分（QS）及高敏C‐反应蛋白（hs‐CRP）水平，判断治疗前后两组患者的腓总神经、正中神经及胫神经的感觉传导速度（SNCV ）、运动传导速度（M NCV ）变化情况，分析临床疗效。【结果】观察组治疗总有效率为92．68％，对照组为70．73％，观察组治疗有效率显著高于对照组，且两组相比较差异有显著性（ P ＜0．05）；两组患者治疗前后收缩压、舒张压对比均无明显差异（ P ＞0．05）；两组治疗前后三酰甘油（TG）、总胆固醇（TC）、低密度脂蛋白（LDL‐C）、高密度脂蛋白（HDL‐C）、糖化血红蛋白（HbA1c）相比较差异均无显著性（ P＞0．05）；两组患者M NCV、SNCV评分较治疗前均有明显改善，且观察组治疗后评分优于对照组（ P ＜0．05）；QS评分治疗后明显低于治疗前，且观察组显著低于对照组（ P ＜0．05）；hs‐CRP水平经治疗后，两组患者均有下降，观察组明显低于对照组（ P ＜0．05）。【结论】鼠神经神长因子对糖尿病周围神经病变治疗效果显著，可有效提高患者生活质量，值得临床进一步推广使用。
【목적】탐토서신경생장인자대당뇨병주위신경병변적림상치료효과。【방법】선택본원2012년3월지2014년2월수치적82례당뇨병주위신경병변환자위연구대상，수궤분위대조조여관찰조，매조41례환자，대조조채취갑고알주사액치료，관찰조행서신경생장인자기육주사치료，대량조환자치료전후적혈압、혈지、혈당수평진행분석，병관찰비교량조환자치료전후수면질량평분（QS）급고민C‐반응단백（hs‐CRP）수평，판단치료전후량조환자적비총신경、정중신경급경신경적감각전도속도（SNCV ）、운동전도속도（M NCV ）변화정황，분석림상료효。【결과】관찰조치료총유효솔위92．68％，대조조위70．73％，관찰조치료유효솔현저고우대조조，차량조상비교차이유현저성（ P ＜0．05）；량조환자치료전후수축압、서장압대비균무명현차이（ P ＞0．05）；량조치료전후삼선감유（TG）、총담고순（TC）、저밀도지단백（LDL‐C）、고밀도지단백（HDL‐C）、당화혈홍단백（HbA1c）상비교차이균무현저성（ P＞0．05）；량조환자M NCV、SNCV평분교치료전균유명현개선，차관찰조치료후평분우우대조조（ P ＜0．05）；QS평분치료후명현저우치료전，차관찰조현저저우대조조（ P ＜0．05）；hs‐CRP수평경치료후，량조환자균유하강，관찰조명현저우대조조（ P ＜0．05）。【결론】서신경신장인자대당뇨병주위신경병변치료효과현저，가유효제고환자생활질량，치득림상진일보추엄사용。
[Objective] To explore the clinical efficacy of mouse nerve growth factor for peripheral diabetic neuropathy .[Methods] From March 2012 to February 2014 ,a total of 82 patients with peripheral diabetic neuropathy were recruited and randomly divided into observation and control groups ( n=41 each) .The con‐trol group received an injection of mecobalamin while the observation group had an intramuscular injection of mouse nerve growth factor .The blood levels of fat ,sugar and high sensitivity C‐reactive protein (hs‐CRP) , blood pressure ,sleep quality score ,sensory nerve conduction velocity (SNCV)& motor nerve conduction ve‐locity (MNCV) and clinical efficacies were compared before and after treatment .[Results]The overall efficacy rate of observation group was higher than that of control group (92 .68% vs 70 .73% ,P <0 .05) .Systolic or diastolic blood pressure showed no obvious inter‐group difference ( P < 0 .05) .two group have no obvious difference from the comparison of total cholesterol (TC) ,TG ,low density lipoprotein‐cholesterol (LDL‐C) , high density lipoprotein‐cholesterol (HDL‐C) and HbA1c before treatment ,which also has no statistic signifi‐cance after treatment ( P>0 .05) .The post and pre‐treatment scores of MNCV and SNCV had obvious differ‐ences .However ,observation group fared better than control group after treatment ( P<0 .05) And the post‐treatment QS score of observation group was obviously lower than that of control group ( P <0 .05) .After treatment ,hs‐CRP decreased in both groups .However ,there was a greater decline in observation group ( P<0 .05) .[Conclusion]Mouse nerve growth factor has marked efficacy for peripheral diabetic neuropathy so as to effectively improve the patient life quality .And it is worthy of wider popularization .