CAJ | 학술논문

胚胎发育是一个复杂的动态变化过程，频繁改变的基因表达最终导致细胞分化和各种细胞系的形成。这些改变由特定细胞中表观遗传因子所调控。一直以来，人们认为父本表观基因组在胚胎发育中的作用范围很局限。然而，近期精子发生过程中表观遗传修饰的研究显示父本表观基因组在早期胚胎发育过程中具有重要作用。任一表观遗传标记建立和（或）维持的轻微异常均会影响早期胚胎发育过程。现主要综述DNA甲基化和组蛋白修饰的功能作用，阐明了其在胚胎发育和男性不育中的作用机制，为胚胎植入前遗传学诊断提供一些基础材料。
배태발육시일개복잡적동태변화과정，빈번개변적기인표체최종도치세포분화화각충세포계적형성。저사개변유특정세포중표관유전인자소조공。일직이래，인문인위부본표관기인조재배태발육중적작용범위흔국한。연이，근기정자발생과정중표관유전수식적연구현시부본표관기인조재조기배태발육과정중구유중요작용。임일표관유전표기건립화（혹）유지적경미이상균회영향조기배태발육과정。현주요종술DNA갑기화화조단백수식적공능작용，천명료기재배태발육화남성불육중적작용궤제，위배태식입전유전학진단제공일사기출재료。
Embryonic development is a complex and dynamic process with frequent changes in gene expression, ultimately leading to cellular differentiation and formation of various cell lines.These changes are regulated by the epigenetic factors in speciifc cells. The scope of paternal epigenome contributions during embryogenesis has long been considered limited. However, recent studies investigating epigenetic modifications in the spermatogenesis have provided new insights that paternal epigenome may establish a more critical role for the early developing embryo. Perturbations in the establishment and/or maintenance of any epigenetic marks have been demonstrated to affect early embryonic development. This review mainly focus on the functions of DNA methylation and histone modiifcations, elucidate the mechanisms in the regulation of embryogenesis and male infertility, which provides some basic information for preimplantation genetic diagnosis.