中西医结合心脑血管病杂志
中西醫結閤心腦血管病雜誌
중서의결합심뇌혈관병잡지
CHINESE JOURNAL OF INTEGRATIVE MEDICINE ON CARDIO-/CEREBROVASCULAR DISEASE
2015年
5期
625-627
,共3页
老年高血压%内皮功能%血管紧张素Ⅱ%内皮素 1%血管内皮生长因子
老年高血壓%內皮功能%血管緊張素Ⅱ%內皮素 1%血管內皮生長因子
노년고혈압%내피공능%혈관긴장소Ⅱ%내피소 1%혈관내피생장인자
elderly hypertension%endothelial function%Ang Ⅱ%endothelin 1%nitric oxide%Vascular end athelial gronth facfor
目的：探讨老年高血压水平与和血管内皮功能的关系。方法收集2010年9月—2014年5月在我院心内科收治的老年高血压患者182例,根据血压水平将患者分为3组：轻度高血压组62例,中度高血压组63例,重度高血压组57例。收集同期健康体检志愿者55例为对照组。结果与对照组相比,3个高血压组血管紧张素Ⅱ(Ang Ⅱ)、内皮素1(ET 1)和血管内皮生长因子(VEGF)水平较低(P<0.05),一氧化氮(NO)水平较高(P<0.05),随着高血压分级越高,AngⅡ、ET 1和VEGF水平越低(P<0.05),NO水平越高(P<0.05)；相关性分析显示 Ang Ⅱ、ET 1、VEGF水平与血压水平呈正相关关系(r=-0.71、0.68和0.64,P<0.05)；NO与血压水平呈负相关关系(r=-0.62,P<0.05)。结论老年高血压的发生发展与血管内皮功能不全密切相关,内皮功能不全的发生机制与 Ang Ⅱ、ET 1、NO和 VEGF水平密切相关,可通过 Ang Ⅱ、ET 1、NO和 VEGF直接或间接评估内皮功能的改善或受损状况。
目的：探討老年高血壓水平與和血管內皮功能的關繫。方法收集2010年9月—2014年5月在我院心內科收治的老年高血壓患者182例,根據血壓水平將患者分為3組：輕度高血壓組62例,中度高血壓組63例,重度高血壓組57例。收集同期健康體檢誌願者55例為對照組。結果與對照組相比,3箇高血壓組血管緊張素Ⅱ(Ang Ⅱ)、內皮素1(ET 1)和血管內皮生長因子(VEGF)水平較低(P<0.05),一氧化氮(NO)水平較高(P<0.05),隨著高血壓分級越高,AngⅡ、ET 1和VEGF水平越低(P<0.05),NO水平越高(P<0.05)；相關性分析顯示 Ang Ⅱ、ET 1、VEGF水平與血壓水平呈正相關關繫(r=-0.71、0.68和0.64,P<0.05)；NO與血壓水平呈負相關關繫(r=-0.62,P<0.05)。結論老年高血壓的髮生髮展與血管內皮功能不全密切相關,內皮功能不全的髮生機製與 Ang Ⅱ、ET 1、NO和 VEGF水平密切相關,可通過 Ang Ⅱ、ET 1、NO和 VEGF直接或間接評估內皮功能的改善或受損狀況。
목적：탐토노년고혈압수평여화혈관내피공능적관계。방법수집2010년9월—2014년5월재아원심내과수치적노년고혈압환자182례,근거혈압수평장환자분위3조：경도고혈압조62례,중도고혈압조63례,중도고혈압조57례。수집동기건강체검지원자55례위대조조。결과여대조조상비,3개고혈압조혈관긴장소Ⅱ(Ang Ⅱ)、내피소1(ET 1)화혈관내피생장인자(VEGF)수평교저(P<0.05),일양화담(NO)수평교고(P<0.05),수착고혈압분급월고,AngⅡ、ET 1화VEGF수평월저(P<0.05),NO수평월고(P<0.05)；상관성분석현시 Ang Ⅱ、ET 1、VEGF수평여혈압수평정정상관관계(r=-0.71、0.68화0.64,P<0.05)；NO여혈압수평정부상관관계(r=-0.62,P<0.05)。결론노년고혈압적발생발전여혈관내피공능불전밀절상관,내피공능불전적발생궤제여 Ang Ⅱ、ET 1、NO화 VEGF수평밀절상관,가통과 Ang Ⅱ、ET 1、NO화 VEGF직접혹간접평고내피공능적개선혹수손상황。
Objective To study the relationship between endothelial function and blood pressure in elderly hypertension.Methods From September 2010 to May 2014,182 cases elderly hypertensive patients enrol ed into our hospital were divided into 3 groups ac-cording to blood pressure:62 cases ofmild hypertension,63 cases of moderate hypertension and 57 cases ofsevere hypertension.55 cases of healthy volunteers were col ected as the control.Results Compared with the control group,AngⅡ,endothelin 1(ET 1),vas-cular endothelial growth factor(VEGF)were increased (P<0.05),nitric oxide (NO)was decreased(P<0.05)in 3 elderly hyper-tensive groups.AngⅡ,ET 1 and VEGF were increased and NO was decreased with the blood pressure,respectively (P<0.05). Correlation analysis showed that AngⅡ,ET 1 and VEGF were positively correlated with blood pressure (P<0.05).NO was neg-atively correlated with blood pressure (P<0.05).Conclusion The hypertension and endothelial dysfunction are closely related. The endothelial dysfunction can be defined with Ang II,ET 1,NO and VEGF.
