CAJ | 학술논문

目的：观察国产及进口氯吡格雷对左心室射血分数(LVEF)偏低的冠脉介入(PCI)术后患者血液指标、临床症状、远期预后的影响。方法选取2009年1月—2011年1月在我院心内科住院的120例冠心病患者,按入院顺序随机分为两组,每组60例。在常规治疗基础上,对照组加用进口氯吡格雷；治疗组服用国产氯吡格雷,连用1年后,随访患者临床症状,血小板聚集率(ADP IPA),心电图(ECG),左室射血分数(LVEF)等相关指标。结果两组治疗后相对应项比较,血小板计数(t=0.456,P=0.543)；ADP IPA(t=1.056,P=0.654)；临床症状总有效率(χ2=2.16,P=0.19)；LVEF(t=0.469,P=0.511)；6MHW(t=1.123, P=0.672),差异无统计学意义(P>0.05),两种药物疗效相当。结论国产氯吡格雷(泰嘉)能有效预防支架内血栓；改善心绞痛症状,提高运动耐力,并降低再住院率和心脑血管意外,价格低廉,无明显副反应。
목적：관찰국산급진구록필격뢰대좌심실사혈분수(LVEF)편저적관맥개입(PCI)술후환자혈액지표、림상증상、원기예후적영향。방법선취2009년1월—2011년1월재아원심내과주원적120례관심병환자,안입원순서수궤분위량조,매조60례。재상규치료기출상,대조조가용진구록필격뢰；치료조복용국산록필격뢰,련용1년후,수방환자림상증상,혈소판취집솔(ADP IPA),심전도(ECG),좌실사혈분수(LVEF)등상관지표。결과량조치료후상대응항비교,혈소판계수(t=0.456,P=0.543)；ADP IPA(t=1.056,P=0.654)；림상증상총유효솔(χ2=2.16,P=0.19)；LVEF(t=0.469,P=0.511)；6MHW(t=1.123, P=0.672),차이무통계학의의(P>0.05),량충약물료효상당。결론국산록필격뢰(태가)능유효예방지가내혈전；개선심교통증상,제고운동내력,병강저재주원솔화심뇌혈관의외,개격저렴,무명현부반응。
Objective To observe the clinical efficacy of domestic and imported clopidogrel on blood index,clinical symptoms and long term prognosis in patients received percutaneous coronary intervention (PCI)associated with low left ventricular ejection fraction (LVEF).Methods One hundred and twenty patients with coronary artery disease(CAH)were randomly divided into two groups:Treatment group(n=60)treated by domestic clopidogrel,and control group(n=60)treated by imported clopidogrel on the basis of routine treatment for one year. The clinical symptoms,ADP IPA,electrocardiogram(ECG),LVEF were observed. Results After treatment,there was no differences in platelet count(t=0.456,P= 0.543),ADP IPA(t=1.056,P= 0.654),total clinical effective rate(χ2=2.16,P=0.19),LVEF(t=0.469,P=0.511),6 MHW (t=1.123,P=0.672)between two groups.Conclusion Domestic clopidogrel can effectively provent stent thrombosis,improve angina pectoris,increase exercise endurance,reduce readmission rates and cordis and cerebral accidents.It is cheap in price,few side effects.