CAJ | 학술논문

目的：分析急性ST段抬高型心肌梗死（ST segment elevtion myocardical infarction，STEMI）患者血浆B-型钠尿肽（B-type natriuretic peptide，BNP）水平与左室室壁运动积分指数（left ventrcular wall motion score index，LVWMSI）之间的关系，并观察不同BNP水平患者180 d内预后情况。方法收集首次发生的STEMI患者64例，均于发病12 h内急诊行冠状动脉介入治疗。依据BNP水平由低到高将所有研究对象分为4组（按4个百分位数）：A组（BNP≤P25：BNP≤115.25 pg/mL）、B组（P26≤BNP≤P50：115.26~200.5 pg/mL）、C组（P51≤BNP≤P75：200.6~409 pg/mL）、D组（BNP≥P76：BNP≥409 pg/mL）。分析各组间LVWMSI的关系以及BNP水平与LVWMSI的相关关系。随访记录180 d内主要心血管不良事件（major adverse cardiac events，MACE）发生情况，并分析其与血浆BNP水平的关系。结果各组间LVWMSI比较差异均有统计学意义（P<0.05），BNP水平与LVWMSI呈正相关（r=0.73，P<0.01）。随血浆BNP水平增高，各组间近期临床心血管事件呈显著增高趋势（P<0.05）。结论血浆BNP水平能够反应急性心肌梗死患者心功能变化，预测近期预后。
목적：분석급성ST단태고형심기경사（ST segment elevtion myocardical infarction，STEMI）환자혈장B-형납뇨태（B-type natriuretic peptide，BNP）수평여좌실실벽운동적분지수（left ventrcular wall motion score index，LVWMSI）지간적관계，병관찰불동BNP수평환자180 d내예후정황。방법수집수차발생적STEMI환자64례，균우발병12 h내급진행관상동맥개입치료。의거BNP수평유저도고장소유연구대상분위4조（안4개백분위수）：A조（BNP≤P25：BNP≤115.25 pg/mL）、B조（P26≤BNP≤P50：115.26~200.5 pg/mL）、C조（P51≤BNP≤P75：200.6~409 pg/mL）、D조（BNP≥P76：BNP≥409 pg/mL）。분석각조간LVWMSI적관계이급BNP수평여LVWMSI적상관관계。수방기록180 d내주요심혈관불량사건（major adverse cardiac events，MACE）발생정황，병분석기여혈장BNP수평적관계。결과각조간LVWMSI비교차이균유통계학의의（P<0.05），BNP수평여LVWMSI정정상관（r=0.73，P<0.01）。수혈장BNP수평증고，각조간근기림상심혈관사건정현저증고추세（P<0.05）。결론혈장BNP수평능구반응급성심기경사환자심공능변화，예측근기예후。
Objective To investigate the relationship between plasma Brain natriuretic peptide(BNP) level and left ventricular wall motion score index (LVWMSI) in patients with acute ST-segment elevation myocardial infarction (STEMI), and the short term prognosis within 180 days. Methods Sixty four patients with STEMI were treated with primary percutaneous coronary intervention (p-PCI) within 12 h of onset. The BNP level was measured on admission. Based on the BNP level, all patients were divided into four groups (according to the 4 percentile):group A (BNP≤P25:BNP≤115.25 pg/mL), group B(P26≤BNP≤P50:115.26-200.5 pg/mL),group C(P51≤BNP≤P75:200.6-409 pg/mL)and group D(BNP≥P76:BNP≥409 pg/mL). The relationship of BNP level with LVWMSI was analysised. The major adverse cardiac events (MACE) within 180 days were also analyzed. Results The difference of left ventricular wall motion score index among different groups were statistical signiifcant (P<0.05). The levels of BNP and LVWMSI was positively related(r=0.73, P<0.01). Along with the increase of plasma BNP level, major adverse cardiac events increased signiifcantly (P<0.05). Conclusion Plasma BNP level provides information about the change of heart function and short term prognosis for acute myocardial infarction patients.