CAJ | 학술논문

目的：观察苦橘咳喘合剂的止咳化痰效果,评价其急性毒性。方法采用小鼠氨水引咳实验、小鼠酚红实验、二甲苯小鼠耳廓肿胀实验和最大耐受量实验。结果镇咳实验中苦橘咳喘合剂小、中、大剂量组 R 值分别为112.26%,143.29%,162.07%,分别呈现为无效、有效和显效；苦橘咳喘合剂大、中剂量组能显著增加小鼠气管酚红排泌量,与正常对照组比较差异有统计学意义(P<0.05或P<0.01),且呈现出良好的量效关系；苦橘咳喘合剂小、中、大剂量组均能显著改善二甲苯所致小鼠耳廓肿胀度(P<0.01),且呈现出良好的量效关系；其最大耐受量为326.76 g·kg-1。结论苦橘咳喘合剂中、大剂量具有一定的镇咳祛痰作用和良好的抗炎效果,且安全性较好。
목적：관찰고귤해천합제적지해화담효과,평개기급성독성。방법채용소서안수인해실험、소서분홍실험、이갑분소서이곽종창실험화최대내수량실험。결과진해실험중고귤해천합제소、중、대제량조 R 치분별위112.26%,143.29%,162.07%,분별정현위무효、유효화현효；고귤해천합제대、중제량조능현저증가소서기관분홍배비량,여정상대조조비교차이유통계학의의(P<0.05혹P<0.01),차정현출량호적량효관계；고귤해천합제소、중、대제량조균능현저개선이갑분소치소서이곽종창도(P<0.01),차정현출량호적량효관계；기최대내수량위326.76 g·kg-1。결론고귤해천합제중、대제량구유일정적진해거담작용화량호적항염효과,차안전성교호。
Objective To study the relieving cough and reducing phlegm effects and acute toxicity of the Kujyukekuan mixtures. Methods The method used in our study is a cough model induced by the ammonia water , the phenol red test in mice, the mouse pinna swelling model induced by xylene and the maximum tolerant dose experiment. Results In antitussive experiments, R value of Kujyukekuan mixtures at low, medium and high dose of was 112. 26%, 143. 29%, 162. 07%, respectively regarding as ineffective, effective and marked effective;Kujyukekuan mixtures at medium and high doses increased the excretion of phenolsulfonphthalein in the trachea of mice (compared with the normal control group, P<0. 05 or P<0. 01),the results showed good concentration-response relationship;Kujyukekuan mixtures at low, medium and high dose significantly reduced mouse auricle swelling caused by xylene (compared with normal control group, P<0. 01), the results presented a good concentration-response relationship;the MTD of Kujyukekuan mixture was 326. 76 g·kg-1. Conclusion Kujyukekuan mixtures at medium and high doses exert significant eliminating cough and phlegm effects and strong anti-inflammatory property, and has a good security.