医药导报
醫藥導報
의약도보
HERALD OF MEDICINE
2015年
5期
585-588
,共4页
李伟%熊锦文%陈娟娟%刘涛%肖娟%刘静%张艳丽%冯云%曾雪%陈素华
李偉%熊錦文%陳娟娟%劉濤%肖娟%劉靜%張豔麗%馮雲%曾雪%陳素華
리위%웅금문%진연연%류도%초연%류정%장염려%풍운%증설%진소화
金叶败毒颗粒%巨细胞病毒%感染,宫内
金葉敗毒顆粒%巨細胞病毒%感染,宮內
금협패독과립%거세포병독%감염,궁내
Jingyebaidu granules%Cytomegalovirus%Infection,intrauterine
目的：观察金叶败毒颗粒防治妊娠中期豚鼠巨细胞病毒宫内感染的效果。方法选择无感染史性、成熟期雌雄豚鼠同笼受精,随机选择妊娠中期母豚鼠分为3组,每组15只,正常对照组无特殊处理,模型对照组腹腔接种病毒,金叶败毒组接种病毒同时灌胃给予金叶败毒颗粒(3.09 mL· kg-1),7 d后观察各组母豚鼠病毒血症发生率,20 d后观察各组胎盘感染率、胎仔感染率及死胎率。结果正常对照组和模型对照组死胎率分别为8.33%,34.55%( P<0.05)。模型对照组和金叶败毒组亲代感染率分别为86.67%,33.33%；胎盘感染率分别为91.67%,61.22%；胎仔感染率分别为90.91%,48.28%；死胎率分别为34.55%,15.52%(均P<0.05)。结论金叶败毒颗粒可减少妊娠中期病毒接种引起的母胎感染及胎仔死亡,减少胎盘感染。
目的：觀察金葉敗毒顆粒防治妊娠中期豚鼠巨細胞病毒宮內感染的效果。方法選擇無感染史性、成熟期雌雄豚鼠同籠受精,隨機選擇妊娠中期母豚鼠分為3組,每組15隻,正常對照組無特殊處理,模型對照組腹腔接種病毒,金葉敗毒組接種病毒同時灌胃給予金葉敗毒顆粒(3.09 mL· kg-1),7 d後觀察各組母豚鼠病毒血癥髮生率,20 d後觀察各組胎盤感染率、胎仔感染率及死胎率。結果正常對照組和模型對照組死胎率分彆為8.33%,34.55%( P<0.05)。模型對照組和金葉敗毒組親代感染率分彆為86.67%,33.33%；胎盤感染率分彆為91.67%,61.22%；胎仔感染率分彆為90.91%,48.28%；死胎率分彆為34.55%,15.52%(均P<0.05)。結論金葉敗毒顆粒可減少妊娠中期病毒接種引起的母胎感染及胎仔死亡,減少胎盤感染。
목적：관찰금협패독과립방치임신중기돈서거세포병독궁내감염적효과。방법선택무감염사성、성숙기자웅돈서동롱수정,수궤선택임신중기모돈서분위3조,매조15지,정상대조조무특수처리,모형대조조복강접충병독,금협패독조접충병독동시관위급여금협패독과립(3.09 mL· kg-1),7 d후관찰각조모돈서병독혈증발생솔,20 d후관찰각조태반감염솔、태자감염솔급사태솔。결과정상대조조화모형대조조사태솔분별위8.33%,34.55%( P<0.05)。모형대조조화금협패독조친대감염솔분별위86.67%,33.33%；태반감염솔분별위91.67%,61.22%；태자감염솔분별위90.91%,48.28%；사태솔분별위34.55%,15.52%(균P<0.05)。결론금협패독과립가감소임신중기병독접충인기적모태감염급태자사망,감소태반감염。
Objective To study the effect of Jingyebaidu granules on treating cytomegalovirus ( CMV) infection during mid-pregnancy. Methods The sexually mature guinea pigs with no CMV infection history served as the subjects. Put the male and female ones in the same cages. Then the female ones were randomly divided into three groups during mid-pregnancy. Model control group:15 guinea pigs which were inoculated 1 mL suspension of GPCMV intraperitoneally. Jingyebaidu Medicine group:15 guinea pigs which were treated with Jingyebaidu(3. 09 mL·kg-1 ) through stomach perfusion after inoculation for 14 days. Normal control group:15 normal mid-pregnant guinea pigs. Viremia rates were examined 7 days after infection. All animals were sacrificed 20 days after infection. The placenta infection rate, pup infection rate, still-born rate were examined. Results Compared with the normal controls, the still-born rate was increased in model control group(8. 33% vs 34. 55%, P<0. 05). In comparison to the model control group, the GPCMV maternal infection rate(86. 67% vs 33. 33%), placenta infection rate (91. 67% vs 61. 22%), pup infection rate(90. 91% vs 48. 28%), still-born rate(34. 55% vs 15. 52%) were significantly decreased in the Jinyebaidu group (all P<0. 05). Conclusion Jinyebaidu granules could reduce maternal infection,pup loss, and placenta infection caused by CMV inoculation during mid-pregnancy.
