CAJ | 학술논문

目的：探讨血常规法和基因检测在地中海贫血中的临床价值。方法收集阳江地区600对国家免费孕前优生检验标本（疑似地贫），按照操作规程检验上述对象的MCV、MCH，将初筛结果同地贫基因检测结果进行比较。结果双方夫妻MCV、MCH下降300对（600人），基因检测确诊519人，符合率86.5%；夫妻单方MCV、MCH下降300对（600人），基因确诊244人，符合率81.33%，单方MCV、MCH正常基因携带率4.0%。结论地贫高发地区血常规和基因检测配合应用对地贫的检出有重要的指导意义。
목적：탐토혈상규법화기인검측재지중해빈혈중적림상개치。방법수집양강지구600대국가면비잉전우생검험표본（의사지빈），안조조작규정검험상술대상적MCV、MCH，장초사결과동지빈기인검측결과진행비교。결과쌍방부처MCV、MCH하강300대（600인），기인검측학진519인，부합솔86.5%；부처단방MCV、MCH하강300대（600인），기인학진244인，부합솔81.33%，단방MCV、MCH정상기인휴대솔4.0%。결론지빈고발지구혈상규화기인검측배합응용대지빈적검출유중요적지도의의。
ObjectiveTo investigate the clinical value of blood france and gene test for thalassemia.Methods 600 pairs of pregnancy eugenic test specimens(suspected thalassemia)were selected from Yangjiang area.The MCV and MCH of the specimen were all detected accordance with the rules.The screening results were then compared with gene test results.ResultsMCV and MCH of couples decreased were 300 pairs(600 people),and genetic testing confirmed 519 people.The coincidence rate was 86.5%.MCV and MCH of couples unilateral decreased were 300 pairs(600 people),and genetic testing confirmed 244 people.The coincidence rate was 81.33%.Gene carrying rate of couples unilateral with normal MCV and MCH was 4.0%. Conclusion Blood application with genetic testing has important guiding significance for thalassemia detection of high thalassemia prone areas.