CAJ | 학술논문

目的：针对普外科围术期预防应用抗菌药物情况进行分析和评价，围绕存在问题制定干预措施并实施干预，探讨临床药师参与临床合理用药的模式。方法调查2014年第一季度（即干预前）和2014年第三季度（即干预后）普外科Ⅰ、Ⅱ类切口手术的抗菌药物使用情况，从适应证、给药时机等方面做出用药合理性评估，比较干预前、后的相关指标，评价干预效果。结果经临床药师干预，围术期预防用药在适应证、药物选择、用法用量等方面均明显提高（P<0.05）。结论通过临床药师的用药教育和监督管理及相关行政部门的共同协作等一系列干预措施对指导临床应用抗菌药物有一定的可行性和有效性。
목적：침대보외과위술기예방응용항균약물정황진행분석화평개，위요존재문제제정간예조시병실시간예，탐토림상약사삼여림상합리용약적모식。방법조사2014년제일계도（즉간예전）화2014년제삼계도（즉간예후）보외과Ⅰ、Ⅱ류절구수술적항균약물사용정황，종괄응증、급약시궤등방면주출용약합이성평고，비교간예전、후적상관지표，평개간예효과。결과경림상약사간예，위술기예방용약재괄응증、약물선택、용법용량등방면균명현제고（P<0.05）。결론통과림상약사적용약교육화감독관리급상관행정부문적공동협작등일계렬간예조시대지도림상응용항균약물유일정적가행성화유효성。
Objective To explore the patterns of the clinical rational drug use guided by clinical pharmacists for prophylactic use of antimicrobial agents in department of general surgery during perioperative period according to the problems existed in clinical therapy. Methods The usage condition of antimicrobial agents for the patients with type I ,II incision in department of general surgery in the first quarter of 2014 and the third quarter of 2014 was investagated.The rational assessment was made for the rationality of the medication,indications administration time to compare some relative indexes and to evaluate the effect of before and after the intervention. Results The clinical rational drug use in prophylaxis indication, drug selection, dosage and so on during perioperative period in Department of General Surgery were significantly increased (P<0.05) by intervention of the clinical pharmacist. Conclusions The intervention measures for the guidence of the rational use of antibiotics were effective and feasible.This principle could contribute to improving the rational use of antibiotics,decreasing dosage of the antibiotics. It could also provide a feasible and effective model for the rational clinical pathway to reduce the medical cost.