中国组织工程研究
中國組織工程研究
중국조직공정연구
Journal of Clinical Rehabilitative Tissue Engineering Research
2015年
14期
2278-2282
,共5页
杜伟斌%全仁夫%郑宣%王拓
杜偉斌%全仁伕%鄭宣%王拓
두위빈%전인부%정선%왕탁
干细胞%培养%毛囊干细胞%皮肤修复%早期血管化%信号通路%转录因子%再生医学%组织工程
榦細胞%培養%毛囊榦細胞%皮膚脩複%早期血管化%信號通路%轉錄因子%再生醫學%組織工程
간세포%배양%모낭간세포%피부수복%조기혈관화%신호통로%전록인자%재생의학%조직공정
Hair Follicle%Stem Cells%Wound Healing%Transcription Factors
背景:毛囊干细胞来源于皮肤、毛发,数量极其可观,取材后无严重的并发症和免疫原性,可供自体移植,是最容易获取的干细胞来源之一。目的:综述毛囊干细胞促进皮肤伤口修复的作用因素,以期为该领域研究提供有效的实验依据。方法:应用计算机以“毛囊干细胞、皮肤修复、再生医学、组织工程”或“hair fol icle stem cel ,skin repairing, regenerative medicine,tissue engineering”为检索词检索CNKI 和 PubMed 数据库1999年1月至2014年12月发表的关于毛囊干细胞促进皮肤伤口修复的文章,最终选择45篇文章进行综述。结果与结论:毛囊干细胞作为一种容易获得、数量可观、使用较为安全以及具有分化潜能的成体干细胞,可以通过皮肤早期血管化、表皮及附属器官的再生、信号通路作用及转录因子调节等方面的影响,促进皮肤伤口的修复,能为再生医学及组织工程研究提供良好的种子细胞。
揹景:毛囊榦細胞來源于皮膚、毛髮,數量極其可觀,取材後無嚴重的併髮癥和免疫原性,可供自體移植,是最容易穫取的榦細胞來源之一。目的:綜述毛囊榦細胞促進皮膚傷口脩複的作用因素,以期為該領域研究提供有效的實驗依據。方法:應用計算機以“毛囊榦細胞、皮膚脩複、再生醫學、組織工程”或“hair fol icle stem cel ,skin repairing, regenerative medicine,tissue engineering”為檢索詞檢索CNKI 和 PubMed 數據庫1999年1月至2014年12月髮錶的關于毛囊榦細胞促進皮膚傷口脩複的文章,最終選擇45篇文章進行綜述。結果與結論:毛囊榦細胞作為一種容易穫得、數量可觀、使用較為安全以及具有分化潛能的成體榦細胞,可以通過皮膚早期血管化、錶皮及附屬器官的再生、信號通路作用及轉錄因子調節等方麵的影響,促進皮膚傷口的脩複,能為再生醫學及組織工程研究提供良好的種子細胞。
배경:모낭간세포래원우피부、모발,수량겁기가관,취재후무엄중적병발증화면역원성,가공자체이식,시최용역획취적간세포래원지일。목적:종술모낭간세포촉진피부상구수복적작용인소,이기위해영역연구제공유효적실험의거。방법:응용계산궤이“모낭간세포、피부수복、재생의학、조직공정”혹“hair fol icle stem cel ,skin repairing, regenerative medicine,tissue engineering”위검색사검색CNKI 화 PubMed 수거고1999년1월지2014년12월발표적관우모낭간세포촉진피부상구수복적문장,최종선택45편문장진행종술。결과여결론:모낭간세포작위일충용역획득、수량가관、사용교위안전이급구유분화잠능적성체간세포,가이통과피부조기혈관화、표피급부속기관적재생、신호통로작용급전록인자조절등방면적영향,촉진피부상구적수복,능위재생의학급조직공정연구제공량호적충자세포。
BACKGROUND:Hair fol icle stem cel s derived from skin and hair have the most readily available sources, and cannot lead to serious complications and immunogenicity after col ection, which can be used for autologous transplantation. OBJECTIVE:To provide effective experiment basis for hair fol icle stem cel s in the repair of skin wound through reviewing the role of hair fol icle stem cel s in promote the repair of skin wound. METHODS:Articles related to hair fol icle stem cel s for the repair of skin wound were retrieved in CNKI and PubMed databases (1999-01/2014-12). The key words were“hair fol icle stem cel , skin repairing, regenerative medicine, tissue engineering”in Chinese and English, respectively. A total of 45 articles based on inclusion criteria and exclusion criteria were obtained for the review. RESULTS AND CONCLUSION:Hair fol icle stem cel s belong to adult stem cel s, which are easy to access, have a significant number, and possess differentiation potential and safety. Hair fol icle stem cel s can promote the repair of skin wound and provides good seed cel s for regenerative medicine and tissue engineering research through early vascularization of the skin, epidermal and appendage regeneration, signaling pathways, and transcription factors.