CAJ | 학술논문

目的：探讨非酒精性脂肪性肝病（NAFLD）患者瘦素水平与胆石症及胰岛素抵抗关系。方法选择NAFLD 伴胆石症患者共62例（研究组）和不伴胆石症患者共60例（对照组）。检测两组血清瘦素、空腹血糖（FBG）、空腹胰岛素（FINS）水平；计算胰岛素敏感指数（ISI）、胰岛素抵抗指数（HOMA - IR），观察瘦素水平与其他指标的相关性。结果研究组胰岛素水平、HOMA - IR、瘦素水平显著高于对照组。瘦素与 HOMA - IR、FINS、FBG 等存在较好的相关性。瘦素（OR =2.763）和胰岛素抵抗（OR =1.934）是 NAFLD 合并胆石症的最重要的预测指标。结论 NAFLD 患者血清瘦素水平与胰岛素抵抗密切相关，是反映胆石症形成的一个预测指标。
목적：탐토비주정성지방성간병（NAFLD）환자수소수평여담석증급이도소저항관계。방법선택NAFLD 반담석증환자공62례（연구조）화불반담석증환자공60례（대조조）。검측량조혈청수소、공복혈당（FBG）、공복이도소（FINS）수평；계산이도소민감지수（ISI）、이도소저항지수（HOMA - IR），관찰수소수평여기타지표적상관성。결과연구조이도소수평、HOMA - IR、수소수평현저고우대조조。수소여 HOMA - IR、FINS、FBG 등존재교호적상관성。수소（OR =2.763）화이도소저항（OR =1.934）시 NAFLD 합병담석증적최중요적예측지표。결론 NAFLD 환자혈청수소수평여이도소저항밀절상관，시반영담석증형성적일개예측지표。
Objective To investigate the leptin levels in patients with non - alcoholic fatty liver disease(NAFLD)and its relationship with cholelithiasis and insulin resistance. Methods A total of 62 patients with NAFLD and cholelithiasis(study group)and 60 NAFLD patients without cholelithiasis(control group)were collected. Serum leptin,fasting blood glucose(FBG),fasting insulin(FINS)levels were detected;insulin sensitivity index(ISI)and insulin resistance index(HOMA - IR)were calculated. The relation between leptin and other parameters were observed. Results Insulin,HOMA - IR and leptin levels in study group were significantly higher than control group. There was a good correlation between leptin and HOMA - IR,FINS and FBG. Leptin(OR = 2. 763)and insulin resistance(OR = 1. 934)were the most important predictor of NAFLD and cholelithiasis. Conclusion Serum leptin levels in patients with NAFLD and cholelithiasis are closely related to insulin resistance, which is a predictive indicator of cholelithiasis formation.