中国肝脏病杂志（电子版）
中國肝髒病雜誌（電子版）
중국간장병잡지（전자판）
CHINESE JOURNAL OF LIVER DISEASES(ELECTRONIC VERSION)
2015年
1期
51-54
,共4页
肝小静脉闭塞综合征%土三七%酒精性肝硬化
肝小靜脈閉塞綜閤徵%土三七%酒精性肝硬化
간소정맥폐새종합정%토삼칠%주정성간경화
Hepatic veno-occlusive disease,HVOD%Gynura segetum%Alcoholic liver disease
目的：探讨分析土三七致酒精性肝硬化患者肝小静脉闭塞综合征的临床特点。方法回顾性分析本科室收治的4例酒精性肝硬化患者服用土三七所致的肝小静脉闭塞综合征的临床诊治资料。结果本组病例具有以下临床特点：病例均为男性，年龄在45岁以上；多因骨折、腰痛、腰椎间盘突出等骨伤科疾病服用土三七药酒；均有长期饮酒史，发病前已确诊酒精性肝硬化；患者均有较典型的症状和体征，但没有明显的肝脏增大；病例结合详细的病史、CT或磁共振、下腔静脉造影等可明确诊断；病情的严重程度和服用土三七的总剂量有一定关系。结论土三七引起酒精性肝硬化患者肝小静脉闭塞综合征，长期饮酒、酒精性肝硬化可能是土三七导致HVOD发生的一个重要危险因素。
目的：探討分析土三七緻酒精性肝硬化患者肝小靜脈閉塞綜閤徵的臨床特點。方法迴顧性分析本科室收治的4例酒精性肝硬化患者服用土三七所緻的肝小靜脈閉塞綜閤徵的臨床診治資料。結果本組病例具有以下臨床特點：病例均為男性，年齡在45歲以上；多因骨摺、腰痛、腰椎間盤突齣等骨傷科疾病服用土三七藥酒；均有長期飲酒史，髮病前已確診酒精性肝硬化；患者均有較典型的癥狀和體徵，但沒有明顯的肝髒增大；病例結閤詳細的病史、CT或磁共振、下腔靜脈造影等可明確診斷；病情的嚴重程度和服用土三七的總劑量有一定關繫。結論土三七引起酒精性肝硬化患者肝小靜脈閉塞綜閤徵，長期飲酒、酒精性肝硬化可能是土三七導緻HVOD髮生的一箇重要危險因素。
목적：탐토분석토삼칠치주정성간경화환자간소정맥폐새종합정적림상특점。방법회고성분석본과실수치적4례주정성간경화환자복용토삼칠소치적간소정맥폐새종합정적림상진치자료。결과본조병례구유이하림상특점：병례균위남성，년령재45세이상；다인골절、요통、요추간반돌출등골상과질병복용토삼칠약주；균유장기음주사，발병전이학진주정성간경화；환자균유교전형적증상화체정，단몰유명현적간장증대；병례결합상세적병사、CT혹자공진、하강정맥조영등가명학진단；병정적엄중정도화복용토삼칠적총제량유일정관계。결론토삼칠인기주정성간경화환자간소정맥폐새종합정，장기음주、주정성간경화가능시토삼칠도치HVOD발생적일개중요위험인소。
Objective To analysis and explore the clinical features of hepatic veno-occlusive disease (HVOD) induced by gynura segetum in the patients with alcoholic liver cirrhosis.Methods The data was collected and analysed from 4 patients hospitalized in our department from October 2012 to June 2014. The diagnosis of HVOD for all the patients was made by the drug use history, typical clinical manifestation, biochemical and iconographic examination, CT or MRI.Results The results showed that this group of cases has the following clinical features: all patients are male and the age was elder than 45 years old; all patients with history of long-term use of gynura segetum, one of Chinese medical herbs, because of the suffering orthopaedic disease such as fractures, lumbago, lumbar disc. Before the occuring of HVOD paroxysm, all of the patients had basis of alcoholic liver cirrhosis, with the average of 10 years of alcohol-drinking. All the cases manifested the typical clinical symptoms and sign of HVOD, but without hepatomegaly. The diagnosis of HVOD in all of patients was ifnally conifrmed by both of CT or MRI and Inferior vena cava angiography. There was a positive relationship between the severity of the disease and the total dose of gynura segetum.Conclusions Long-term alcohol drinking may be an important risk factor for the severity of HVOD induce by gynura segetum. It is the ifrst report of hepatic veno-occlusive disease induced by gynura segetum on the basis of alcoholic liver cirrhosis.
