中西医结合心脑血管病杂志
中西醫結閤心腦血管病雜誌
중서의결합심뇌혈관병잡지
CHINESE JOURNAL OF INTEGRATIVE MEDICINE ON CARDIO-/CEREBROVASCULAR DISEASE
2015年
5期
583-584
,共2页
孙志华%贺婕%黄淮
孫誌華%賀婕%黃淮
손지화%하첩%황회
进展性脑梗死%白介素 6%白介素 10%肿瘤坏死因子 α%基因表达
進展性腦梗死%白介素 6%白介素 10%腫瘤壞死因子 α%基因錶達
진전성뇌경사%백개소 6%백개소 10%종류배사인자 α%기인표체
progressive cerebral infarction%interleukin 6%interleukin 10%tumor necrosis factor α%gene expression
目的：探讨急性进展性脑梗死与炎症免疫因子基因表达的关系。方法对38例进展性脑梗死、90例非进展性脑梗死患者进行白介素6(IL 6)、白介素10(IL 10)、肿瘤坏死因子α(TNF α)mRNA表达测定。结果进展性脑梗死组IL 6、IL 10mRNA表达水平明显异常于非进展性脑梗死组(P<0.05)。IL 6mRNA表达水平是脑梗死进展的危险因素。结论外周血炎症免疫因子基因表达水平的异常与进展性脑卒中密切相关，可能参与进展性脑梗死的发病过程中。
目的：探討急性進展性腦梗死與炎癥免疫因子基因錶達的關繫。方法對38例進展性腦梗死、90例非進展性腦梗死患者進行白介素6(IL 6)、白介素10(IL 10)、腫瘤壞死因子α(TNF α)mRNA錶達測定。結果進展性腦梗死組IL 6、IL 10mRNA錶達水平明顯異常于非進展性腦梗死組(P<0.05)。IL 6mRNA錶達水平是腦梗死進展的危險因素。結論外週血炎癥免疫因子基因錶達水平的異常與進展性腦卒中密切相關，可能參與進展性腦梗死的髮病過程中。
목적：탐토급성진전성뇌경사여염증면역인자기인표체적관계。방법대38례진전성뇌경사、90례비진전성뇌경사환자진행백개소6(IL 6)、백개소10(IL 10)、종류배사인자α(TNF α)mRNA표체측정。결과진전성뇌경사조IL 6、IL 10mRNA표체수평명현이상우비진전성뇌경사조(P<0.05)。IL 6mRNA표체수평시뇌경사진전적위험인소。결론외주혈염증면역인자기인표체수평적이상여진전성뇌졸중밀절상관，가능삼여진전성뇌경사적발병과정중。
Objective To investigate the relationship of progressive cerebral infarction (PCI)with serum inflammatory immune factors gene expression.Methods Thirty eight patients with PCI and 90 patients with stabile cerebral infarction were enrol ed.The levels of interleukin(IL) 6,IL 10,tumor necrosis factor α(TNF α)gene expression were measured.Results The levels of IL 6,IL 10 mRNA expression had more significant difference in patients with PCI than that in stabile cerebral infarction.Gene expression of IL 10 was the risk factor in PCI.Conclusion The abnormal levels of inflammatory immune factors mRNA expression may be closely relat-ed to PCI.They may play an important role in progressive ischemic stroke.
