上海医药
上海醫藥
상해의약
SHANGHAI MEDICAL & PHARMACEUTICAL JOURNAL
2015年
9期
28-30
,共3页
氟哌啶醇%外伤后急性弥漫性脑肿胀%平均动脉压%心率%不良反应%蒙特利尔认知评估量表
氟哌啶醇%外傷後急性瀰漫性腦腫脹%平均動脈壓%心率%不良反應%矇特利爾認知評估量錶
불고정순%외상후급성미만성뇌종창%평균동맥압%심솔%불량반응%몽특리이인지평고량표
haloperidol%posttraumatic acute diffuse brain swelling%MAP%HR%adverse reaction%MoCA
目的：观察氟哌啶醇治疗外伤后急性弥漫性脑肿胀（PADBS）患者的疗效和安全性。方法：选取2012年7月至2014年3月期间我院确诊治疗的PADBS患者136例，随机分为对照组和观察组各68例，两组患者均给予手术、亚低温等常规治疗，观察组在此基础上给予氟哌啶醇治疗，统计分析所有患者平均动脉压（MAP）、心率（HR）和不良反应发生情况，采用蒙特利尔认知评估（MoCA）量表评估患者认知功能。结果：观察组治疗有效率明显高于对照组；MAP、HR、MoCA得分明显优于对照组，差异均有统计学意义。观察组患者不良反应发生比例高于对照组，但差异无统计学意义。结论：氟哌啶醇治疗可有效提高外伤后PADBS患者的疗效，有利于改善患者预后，且无明显增加患者不良反应的风险。
目的：觀察氟哌啶醇治療外傷後急性瀰漫性腦腫脹（PADBS）患者的療效和安全性。方法：選取2012年7月至2014年3月期間我院確診治療的PADBS患者136例，隨機分為對照組和觀察組各68例，兩組患者均給予手術、亞低溫等常規治療，觀察組在此基礎上給予氟哌啶醇治療，統計分析所有患者平均動脈壓（MAP）、心率（HR）和不良反應髮生情況，採用矇特利爾認知評估（MoCA）量錶評估患者認知功能。結果：觀察組治療有效率明顯高于對照組；MAP、HR、MoCA得分明顯優于對照組，差異均有統計學意義。觀察組患者不良反應髮生比例高于對照組，但差異無統計學意義。結論：氟哌啶醇治療可有效提高外傷後PADBS患者的療效，有利于改善患者預後，且無明顯增加患者不良反應的風險。
목적：관찰불고정순치료외상후급성미만성뇌종창（PADBS）환자적료효화안전성。방법：선취2012년7월지2014년3월기간아원학진치료적PADBS환자136례，수궤분위대조조화관찰조각68례，량조환자균급여수술、아저온등상규치료，관찰조재차기출상급여불고정순치료，통계분석소유환자평균동맥압（MAP）、심솔（HR）화불량반응발생정황，채용몽특리이인지평고（MoCA）량표평고환자인지공능。결과：관찰조치료유효솔명현고우대조조；MAP、HR、MoCA득분명현우우대조조，차이균유통계학의의。관찰조환자불량반응발생비례고우대조조，단차이무통계학의의。결론：불고정순치료가유효제고외상후PADBS환자적료효，유리우개선환자예후，차무명현증가환자불량반응적풍험。
Objective: To investigate the efficacy and safety of haloperidol in the treatment of patients with posttraumatic acute diffuse brain swelling (PADBS).Methods: One hundred and thirty-six patients with PADBS in our hospital were randomly divided into a control group and an observation group with 68 cases each. Conventional treatments including operation and hypothermia treatment were given in two groups, and in addition, haloperidol was given in the observation group. Mean arterial pressure (MAP), heart rate (HR) and adverse reactions of all the patients were analyzed. Montreal cognitive assessment (MoCA) scale was used to assess the cognitive function of the patients.Results: The treatment efficiency of the observation group was higher than that of the control group, and the MAP, HR, MoCA scale were also better in the observation group than in the control group. All the differences are statistically signiifcant. The incidence of adverse reaction was higher in the observation group than in the control group, however there was no statistical signiifcance in differences.Conclusion:Haloperidol can effectively improve the efifcacy of patients with PADBS, and is of beneift to the prognosis of patients without signiifcant risk of increasing adverse reactions.
