CAJ | 학술논문

癫痫并非完全是一类终身疾病，60%~70%的患者的症状在经过一定时间的抗癫痫药治疗后能得到缓解（≥5年不发作）。癫痫缓解后考虑抗癫痫药撤药时需对患者进行综合评估、包括撤药后的癫痫复发风险及获益评估。患者长时间使用抗癫痫药可出现药物不良反应，但撤药后癫痫复发也会给患者带来负面影响。对抗癫痫药撤药的研究已有60多年的历史，但目前临床上对能撤药的条件、时机和具体方法尚无统一的标准。本文就抗癫痫药撤药的时机和速度、撤药对癫痫复发的影响及危险因素等方面的研究进展进行综述。
전간병비완전시일류종신질병，60%~70%적환자적증상재경과일정시간적항전간약치료후능득도완해（≥5년불발작）。전간완해후고필항전간약철약시수대환자진행종합평고、포괄철약후적전간복발풍험급획익평고。환자장시간사용항전간약가출현약물불량반응，단철약후전간복발야회급환자대래부면영향。대항전간약철약적연구이유60다년적역사，단목전림상상대능철약적조건、시궤화구체방법상무통일적표준。본문취항전간약철약적시궤화속도、철약대전간복발적영향급위험인소등방면적연구진전진행종술。
Epilepsy is not completely a lifelong disease, about 60% ~ 70% of patients can be relieved (no attack within at least 5 years) after a certain period of anti-epileptic drugs (AEDs) treatment. Making a decision to withdraw AEDs in patients with epilepsy in remission requires a careful assessment to the patients, including the associated risks and beneifts. Unnecessary continuation of AEDs will expose the patients to unwarranted adverse drug reaction, however premature withdrawal with subsequent seizure recurrence may be distressing for the patients. Although it has been 60 years since researchers began studying the withdrawal of AEDs, there are still no uniifed standards about the time, requirements or speciifc methods for withdrawal. This article reviews when and how to withdraw AEDs, the effects of withdrawal on relapse, the risk factors of relapse after drug withdrawal and so on.