CAJ | 학술논문

抗癫痫药物按作用机制可分为膜稳定剂、减少神经递质释放的药物、提高γ-氨基丁酸能的药物和其他4类。许多抗癫痫药物的作用机制复杂，致使临床中治疗药物的选择及其不良反应均存在不确定性。有些抗癫痫药物有肝酶诱导或抑制作用，故在多药联合治疗或与其他药物合并使用时的代谢速率发生改变。临床上应注意抗癫痫药物的非特异性不良反应，如困倦、头晕等；也应注意各种抗癫痫药物治疗的比较严重的特异性不良反应，如拉莫三嗪可引起严重皮疹、卡马西平会引起白细胞计数降低等。
항전간약물안작용궤제가분위막은정제、감소신경체질석방적약물、제고γ-안기정산능적약물화기타4류。허다항전간약물적작용궤제복잡，치사림상중치료약물적선택급기불량반응균존재불학정성。유사항전간약물유간매유도혹억제작용，고재다약연합치료혹여기타약물합병사용시적대사속솔발생개변。림상상응주의항전간약물적비특이성불량반응，여곤권、두훈등；야응주의각충항전간약물치료적비교엄중적특이성불량반응，여랍막삼진가인기엄중피진、잡마서평회인기백세포계수강저등。
According to drug mechanism, antiepileptic drugs can be divided into four groups: membrane stabilization, reducing neurotransmitters release, increasing γ-aminobutyric acid mediated inhibition, and the others. Many antiepileptic drugs have more than one mechanism, leading to the uncertainty of drug selection and adverse effects. Some antiepileptic drugs are liver enzyme inducers or inhibitors, resulting in changes in the metabolism, when used in multiple treatment or in combination with other drugs. Antiepileptic drugs have not only non-speciifc side effects such as drowsiness and dizziness, but also a variety of speciifc serious adverse effects such as severe rashes caused by lamotrigine and leukopenia caused by carbamazepine.