CAJ | 학술논문

DEK是多细胞生物细胞内含量丰富的可磷酸化的核蛋白，序列高度保守且无其他亚型。DEK主要在增殖活跃的细胞和癌细胞中高表达。最早在急性髓性白血病的一个亚型中以DEK-CAN融合蛋白的形式被发现，近年报道表明DEK在人类肿瘤中具有重要作用。多种恶性肿瘤如肝细胞癌、胶质母细胞瘤、视网膜母细胞瘤、膀胱癌、恶性黑色素瘤和宫颈癌中均有过表达。DEK是一种促进肿瘤细胞生长、浸润的染色质调节蛋白。本综述结合最新进展对DEK和肿瘤的关系作了全面的综述。
DEK시다세포생물세포내함량봉부적가린산화적핵단백，서렬고도보수차무기타아형。DEK주요재증식활약적세포화암세포중고표체。최조재급성수성백혈병적일개아형중이DEK-CAN융합단백적형식피발현，근년보도표명DEK재인류종류중구유중요작용。다충악성종류여간세포암、효질모세포류、시망막모세포류、방광암、악성흑색소류화궁경암중균유과표체。DEK시일충촉진종류세포생장、침윤적염색질조절단백。본종술결합최신진전대DEK화종류적관계작료전면적종술。
DEK protein is an abundant chromatin protein in metazoans with highly conserved nuclear factor. This protein is a unique member of its family and is preferentially expressed in actively proliferating and malignant cells. Recently, much attention has been paid to the role of DEK protein in the development of various cancers, which was originally discovered in a subset of acute my-elogenous leukemia. Oncogene DEK is overexpressed in several malignancies including hepatocellular carcinoma, glioblastoma, retino-blastoma, bladder cancer, malignant melanoma, and cervical cancer. Oncogene DEK is a chromatin remodeling protein that supports cancer cell proliferation and invasion. In this review, we summarized research advancements in the correlation between DEK protein and oncogenesis.