中国肿瘤临床
中國腫瘤臨床
중국종류림상
CHINESE JOURNAL OF CLINICAL ONCOLOGY
2015年
9期
457-459
,共3页
张高嘉%王俊锋%李万荣%张云鹏%沈志祥
張高嘉%王俊鋒%李萬榮%張雲鵬%瀋誌祥
장고가%왕준봉%리만영%장운붕%침지상
胃癌%低分化腺癌%骨转移%转移途径
胃癌%低分化腺癌%骨轉移%轉移途徑
위암%저분화선암%골전이%전이도경
gastric cancer%poorly differentiated adenocarcinoma%bone metastasis%route of metastases
据文献报道胃癌伴有骨转移发生率为0.46%~38%,胃癌伴骨转移的高危因素包括:年轻患者、病理为低分化腺癌、BorrmannⅢ型、浸润深度T3和T4、伴多发淋巴转移和胃体部肿瘤。转移途径半数以上为非门脉系统。胃癌伴骨转移而无肝转移病例占69%,骨转移与淋巴转移区站转移有密切关联,距胃原发病灶3 cm以上存在淋巴转移者,其骨转移发生率为27%。核素扫描为骨转移提供了诊断途径和可靠的依据,HCG、CEA肿瘤标志物检测对诊断骨转移有所帮助,治疗以放化疗为主。骨转移预后较差,大多生存期<6个月。
據文獻報道胃癌伴有骨轉移髮生率為0.46%~38%,胃癌伴骨轉移的高危因素包括:年輕患者、病理為低分化腺癌、BorrmannⅢ型、浸潤深度T3和T4、伴多髮淋巴轉移和胃體部腫瘤。轉移途徑半數以上為非門脈繫統。胃癌伴骨轉移而無肝轉移病例佔69%,骨轉移與淋巴轉移區站轉移有密切關聯,距胃原髮病竈3 cm以上存在淋巴轉移者,其骨轉移髮生率為27%。覈素掃描為骨轉移提供瞭診斷途徑和可靠的依據,HCG、CEA腫瘤標誌物檢測對診斷骨轉移有所幫助,治療以放化療為主。骨轉移預後較差,大多生存期<6箇月。
거문헌보도위암반유골전이발생솔위0.46%~38%,위암반골전이적고위인소포괄:년경환자、병리위저분화선암、BorrmannⅢ형、침윤심도T3화T4、반다발림파전이화위체부종류。전이도경반수이상위비문맥계통。위암반골전이이무간전이병례점69%,골전이여림파전이구참전이유밀절관련,거위원발병조3 cm이상존재림파전이자,기골전이발생솔위27%。핵소소묘위골전이제공료진단도경화가고적의거,HCG、CEA종류표지물검측대진단골전이유소방조,치료이방화료위주。골전이예후교차,대다생존기<6개월。
The bone is a common site of metastasis for gastric cancer. High-risk factors of metastatic gastric cancer include young age, poorly differentiated adenocarcinoma, Borrmann type III tumors, depth of invasion at Se and Pm levels, positive lymph nodes, and gastric cancer with concomitant body of stomach cancer. More than half of the transfer pathway belongs to the non-portal system. Cases of gastric cancer with bone metastasis but without liver metastasis accounted for 69%of the total gastric cancer cases, whereas the incidence rate of bone metastasis with lymph node metastasis (≥3 cm away from the primary lesion) was 27%. In addition to the tumor markers human chorionic gonadotropin and carcinoembryonic antigen, radionuclide scan of the bone metastasis provides diagnostic pathways and reliable basis for treatment. Chemoradiation and surgery as symptomatic treatments are alternative therapies for stomach cancer. Bone metastasis confers unfavorable prognosis, and the survival time is often less than six months.