临床和实验医学杂志
臨床和實驗醫學雜誌
림상화실험의학잡지
JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
2015年
9期
710-712
,共3页
异位妊娠%解整合素 - 金属蛋白质酶%早期诊断
異位妊娠%解整閤素 - 金屬蛋白質酶%早期診斷
이위임신%해정합소 - 금속단백질매%조기진단
Ectopic pregnancy%A disintegrin and metalloprotease%Early diagnosis
目的：观察解整合素-金属蛋白质酶12- S（ADAM12- S）在异位妊娠及正常妊娠过程中的变化特点，探讨 ADAM12- S 在异位妊娠早期诊断中的临床价值。方法将146例异位妊娠患者设为异位妊娠组，263例正常孕妇为对照组，观察两组研究对象不同孕周的 ADAM12- S 检测情况，以及 ADAM12- S 与孕周相关性。结果异位妊娠组平均 ADAM12- S 对数值在不同孕周均低于同期正常妊娠组，差异有统计学意义（ P <0.05）；正常对照组 ADAM12- S 对数值与孕周呈线性关系（ r =0.926，P =0.000，P <0.01），回归方程 Y =0.3147X -0.3099，ADAM12- S 对数值随孕周增加而上升；异位妊娠组 ADAM12- S 对数值与孕周经直线相关回归性分析，无线性关系（ r =-0.119，P =0.140，P >0.05）。结论 ADAM12- S 在妊娠早期阶段能较好地反映胎盘功能情况，可作为异位妊娠诊断的辅助检查指标。
目的：觀察解整閤素-金屬蛋白質酶12- S（ADAM12- S）在異位妊娠及正常妊娠過程中的變化特點，探討 ADAM12- S 在異位妊娠早期診斷中的臨床價值。方法將146例異位妊娠患者設為異位妊娠組，263例正常孕婦為對照組，觀察兩組研究對象不同孕週的 ADAM12- S 檢測情況，以及 ADAM12- S 與孕週相關性。結果異位妊娠組平均 ADAM12- S 對數值在不同孕週均低于同期正常妊娠組，差異有統計學意義（ P <0.05）；正常對照組 ADAM12- S 對數值與孕週呈線性關繫（ r =0.926，P =0.000，P <0.01），迴歸方程 Y =0.3147X -0.3099，ADAM12- S 對數值隨孕週增加而上升；異位妊娠組 ADAM12- S 對數值與孕週經直線相關迴歸性分析，無線性關繫（ r =-0.119，P =0.140，P >0.05）。結論 ADAM12- S 在妊娠早期階段能較好地反映胎盤功能情況，可作為異位妊娠診斷的輔助檢查指標。
목적：관찰해정합소-금속단백질매12- S（ADAM12- S）재이위임신급정상임신과정중적변화특점，탐토 ADAM12- S 재이위임신조기진단중적림상개치。방법장146례이위임신환자설위이위임신조，263례정상잉부위대조조，관찰량조연구대상불동잉주적 ADAM12- S 검측정황，이급 ADAM12- S 여잉주상관성。결과이위임신조평균 ADAM12- S 대수치재불동잉주균저우동기정상임신조，차이유통계학의의（ P <0.05）；정상대조조 ADAM12- S 대수치여잉주정선성관계（ r =0.926，P =0.000，P <0.01），회귀방정 Y =0.3147X -0.3099，ADAM12- S 대수치수잉주증가이상승；이위임신조 ADAM12- S 대수치여잉주경직선상관회귀성분석，무선성관계（ r =-0.119，P =0.140，P >0.05）。결론 ADAM12- S 재임신조기계단능교호지반영태반공능정황，가작위이위임신진단적보조검사지표。
Objective To observe a disintegrin and metalloprotease(ADAM)12 - S changes in ectopic and normal pregnancy,and to explore the clinical value of ADAM12 - S in the early diagnosis of ectopic pregnancy. Methods One hundred forty - six cases of ectopic pregnan-cy were set as ectopic pregnancy group,263 normal pregnant women as control group. ADAM12 - S was detected in two groups of subjects in dif-ferent pregnant weeks and the relationship between ADAM12 - S and gestational weeks was analyzed. Results Average ADAM12 - S values at different gestational age for ectopic pregnancy group were lower than the same period in normal pregnancy group,the difference was statistically sig-nificant( P < 0. 05). A positive linear correlation was found between the logarithm of ADAM12 - S and gestational age( r = 0. 926,P = 0. 000, P < 0. 01)in the control group(the regression equation was y = 0. 3147X - 0. 3099). No linear relationship was found between the logarithm of ADAM12 - S and gestational age in ectopic pregnancy group( r = - 0. 119,P = 0. 140,P > 0. 05). Conclusion ADAM12 - S can reflect pla-cental function in the early stages of pregnancy and can be used as an auxiliary indicator for the diagnosis of ectopic pregnancy.
