CAJ | 학술논문

目的：研究甲基丙烯酸甲酯溶液对蟾蜍离体坐骨神经动作电位传导的影响。方法制备蟾蜍离体坐骨神经标本，随机将标本分为4组：任氏液对照组，0.01%、0.1%和1%甲基丙烯酸甲酯溶液组。采用 BL -420生物信号采集系统记录标本动作电位的振幅和传导速度。结果蟾蜍坐骨神经动作电位振幅为（5.28±0.16）mV，传导速度为（15.63±0.47）m/ s。给药后0.01%组的振幅在第3~15分钟时出现“高台期”，最终降至（2.53±0.21）mV，传导速度在第10分钟开始下降，实验结束时为（8.06±0.77）m/ s。0.1%组在第1~15分钟为“高台期”，但最终降至（1.88±0.14） mV，传导速度在第5分钟下降，实验结束时为（2.81±0.51）m/ s。1%组在试验结束时振幅为（1.37±0.12）mV，传导速度在第2分钟下降，实验末为（2.73±0.43）m/ s。结论甲基丙烯酸甲酯溶液可以降低神经动作电位振幅及传导速度。中低浓度的甲基丙烯酸甲酯可以在短时间内提高动作电位振幅，但长时间作用于神经仍会减弱振幅，高浓度溶液则不会出现振幅升高的现象。甲基丙烯酸甲酯对神经传导的影响可能是经皮椎体成形术（PVP）手术止痛的原因之一。
목적：연구갑기병희산갑지용액대섬서리체좌골신경동작전위전도적영향。방법제비섬서리체좌골신경표본，수궤장표본분위4조：임씨액대조조，0.01%、0.1%화1%갑기병희산갑지용액조。채용 BL -420생물신호채집계통기록표본동작전위적진폭화전도속도。결과섬서좌골신경동작전위진폭위（5.28±0.16）mV，전도속도위（15.63±0.47）m/ s。급약후0.01%조적진폭재제3~15분종시출현“고태기”，최종강지（2.53±0.21）mV，전도속도재제10분종개시하강，실험결속시위（8.06±0.77）m/ s。0.1%조재제1~15분종위“고태기”，단최종강지（1.88±0.14） mV，전도속도재제5분종하강，실험결속시위（2.81±0.51）m/ s。1%조재시험결속시진폭위（1.37±0.12）mV，전도속도재제2분종하강，실험말위（2.73±0.43）m/ s。결론갑기병희산갑지용액가이강저신경동작전위진폭급전도속도。중저농도적갑기병희산갑지가이재단시간내제고동작전위진폭，단장시간작용우신경잉회감약진폭，고농도용액칙불회출현진폭승고적현상。갑기병희산갑지대신경전도적영향가능시경피추체성형술（PVP）수술지통적원인지일。
Objective To study the effect of the methylmethacrylate( MMA)on action potential of the sciatic nerve. Methods The nerves were impacted by 0. 01% ,0. 1% and 1% methylmethacrylate respectively. The amplitude and conduction velocity of the sciatic nerves was recorded by BL - 420 biological experimental system. Results The amplitude of nerves is(5. 28 ± 0. 16)mV and the velocity is(15. 63 ± 0. 47) m/ s. The amplitude appeared a "high level stage" in 0. 01% group at 3rd to 15th minute. The amplitude was(2. 53 ± 0. 21)mV and the velocity was(8. 06 ± 0. 77)m/ s at the end of the study. In the 0. 1% group,the period of whose "high level stage" of amplitude is 1st to 15th minute. The amplitude was(1. 88 ± 0. 14)mV and the velocity was(2. 81 ± 0. 51)m/ s at last. There was no "high level stage" in 1% group. The ampli-tude was(1. 37 ± 0. 12)mV at last. However,the velocity went to(2. 73 ± 0. 43)m/ s at the end of experiment. Conclusion The amplitude and velocity of action potential were impacted markedly by MMA. The low and moderate concentrate MMA could increase the amplitude in a short time, but it still decreased when the experiment continued. However,this phenomenon was not manifest in high concentrate. The impact on never would explain the reason why PVP relief pain.