CAJ | 학술논문

泛素—蛋白酶体系统通过调控关键蛋白的泛素化和去泛素化介导多种细胞活动。泛素羧基末端水解酶在多种肿瘤组织中表达异常，作为去泛素化酶家族成员，可移除泛素化蛋白上的泛素分子，从而介导肿瘤发生中关键蛋白的泛素化水平，参与多种肿瘤的发生发展过程。本文对泛素羧基末端水解酶家族成员特点及其在肿瘤发生发展中的作用进行综述，以期为寻找肿瘤治疗新靶点提供线索。
범소—단백매체계통통과조공관건단백적범소화화거범소화개도다충세포활동。범소최기말단수해매재다충종류조직중표체이상，작위거범소화매가족성원，가이제범소화단백상적범소분자，종이개도종류발생중관건단백적범소화수평，삼여다충종류적발생발전과정。본문대범소최기말단수해매가족성원특점급기재종류발생발전중적작용진행종술，이기위심조종류치료신파점제공선색。
By regulating the ubiquitination and deubiquitination of key proteins , ubiquitin-proteasome system mediates a variety of cellular activities . Ubiquitin C-terminal hydrolase ( UCH) is a deubiquitinating enzyme which can remove ubiquitin chains at the end of ubiquited proteins .The abnormal expression of UCH has been found in a variety of tumor tissues , indicating that it participates in the process of tumor development . Here we review the characteristics of UCH members and current understanding about the role of UCH in tumor development , and the potential target for cancer treatment .